尿毒症患者行持续性腹膜透析治疗对临床效果、钙磷代谢及炎症因子的影响  

Effect of Continuous Peritoneal Dialysis Treatment on Clinical Effect,Calcium and Phosphorus Metabolism and Inflammatory Factors in Patients with Uremia

作　　者：徐向君[1] XU Xiangjun(Department of Nephrology,Yixing People's Hospital,Yixing,Jiangsu Province,214200 China)

机构地区：[1]宜兴市人民医院肾内科,江苏宜兴214200

出　　处：《中外医疗》2022年第1期13-16,共4页China & Foreign Medical Treatment

摘　　要：目的研究分析持续性腹膜透析治疗尿毒症患者的效果。方法随机选取2018年1月—2020年12月期间该院收治的100例尿毒症患者进行研究,遵循双盲法随机分为两组,其中50例患者为对照组,50例患者为观察组。对照组采用持续性血液透析治疗,观察组采用持续性腹膜透析治疗,以两组患者临床疗效以及治疗前、治疗后6个月钙磷代谢、炎症因子为观察指标,之后对观察结果进行统计比较。结果观察组临床总有效率为96.00%,显著高于对照组,差异有统计学意义(χ^(2)=6.061,P<0.05)。治疗前,观察组与对照组血钙、血磷比较差异无统计学意义(P>0.05);治疗后6个月,观察组血钙、血磷水平分别为(2.16±0.32)、(1.81±0.34)mmol/L,显著低于对照组,差异有统计学意义(t=2.982、2.766,P<0.05)。治疗前,观察组与对照组超敏-C反应蛋白、肿瘤坏死因子-α、白细胞介素-6水平对比差异无统计学意义(P>0.05);治疗后6个月,观察组超敏-C反应蛋白、肿瘤坏死因子-α、白细胞介素-6水平分别为(5.31±1.66)mg/L、(23.28±4.61)ng/L、(14.89±3.31)ng/L,显著低于对照组,差异有统计学意义(t=6.306、6.872、6.849,P<0.05)。结论持续性腹膜透析治疗尿毒症患者的效果更加确切,不仅能够调节患者钙磷代谢情况,还可以减轻患者炎症反应,值得临床推荐应用。Objective To study and analyze the effect of continuous peritoneal dialysis in the treatment of patients with uremia.Methods A total of 100 patients with uremia admitted to the hospital from January 2018 to December 2020 were randomly selected for research.Following the double-blind method,they were randomly divided into two groups,of which 50 patients were the control group and 50 patients were the observation group.The control group was treated with continuous hemodialysis,and the observation group was treated with continuous peritoneal dialysis.The clinical efficacy of the two groups of patients,calcium and phosphorus metabolism,and inflammatory factors before treatment and 6 months after treatment were used as observation indicators.Then statistically compare the observation results.Results The total clinical effective rate of the observation group was 96.00%,which was significantly higher than that of the control group,and the difference was statistically significant(χ^(2)=6.061,P<0.05).Before treatment,there was no statistically significant difference in blood calcium and phosphorus between the observation group and the control group(P>0.05).6 months after treatment,the blood calcium and phosphorus levels of the observation group were(2.16±0.32)mmol/L and(1.81±0.34)mmol/L,respectively,which were significantly lower than those of the control group,and the difference was statistically significant(t=2.982,2.766,P<0.05).Before treatment,there was no statistically significant difference between the observation group and the control group in the levels of hypersensitivity-C-reactive protein,tumor necrosis factor-α,and interleukin-6(P>0.05).6 months after treatment,the levels of hypersensitivity-C-reactive protein,tumor necrosis factor-α,and interleukin-6 in the observation group were(5.31±1.66)mg/L,(23.28±4.61)ng/L,(14.89±3.31)ng/L,significantly lower than the control group,and the difference was statistically significant(t=6.306,6.872,6.849,P<0.05).Conclusion The effect of continuous peritoneal dialysis

关 键 词：尿毒症 持续性腹膜透析 临床疗效 钙磷代谢 炎症因子 

分 类 号：R459[医药卫生—治疗学]