前列地尔联合异丙嗪治疗急诊眩晕患者的疗效及安全性研究  

Study on the Efficacy and Safety of Alprostadil Combined with Promethazine in the Treatment of Patients with Vertigo in Emergency

作　　者：陈国权 黄伟柱 刘凤英[1] 宋治洁[1] 温丹[1] 罗志东 CHEN Guoquan;HUANG Weizhu;LIU Fengying;SONG Zhijie;WEN Dan;LUO Zhidong(Department of Neurology,Huangjiang Hospital of Dongguan City,Dongguan,Guangdong Province,523750 China)

机构地区：[1]东莞市黄江医院神经内科,广东东莞523750

出　　处：《中外医疗》2022年第1期100-103,共4页China & Foreign Medical Treatment

基　　金：东莞市社会科技发展(一般)项目(202050715041174)。

摘　　要：目的研究前列地尔联合异丙嗪治疗急诊眩晕患者的总体效果,重点评估两种药物联用的治疗有效性和安全性。方法方便选取该院在2019年1—12月收治的104例急诊眩晕患者作为研究对象,以随机数表法分组,每组52例。对照组患者采用前列地尔治疗,观察组患者在前列地尔的基础上增加异丙嗪治疗。比较两种治疗方案对临床疗效和用药安全性。结果观察组的总有效率为96.15%,显著高于对照组的84.62%,差异有统计学意义(χ^(2)=3.983,P<0.05);治疗后两组的凝血功能指标与治疗前相比均发生了改变,观察组长于对照组,差异有统计学意义(P<0.05),两组治疗后患者的纤维蛋白原水平均低于治疗前,观察组低于对照组,差异有统计学意义(P<0.05);治疗后两组患者的血常规较治疗前均有改善,且观察组的各项指标均优于对照组,差异有统计学意义(P<0.05);治疗期间观察组和对照组患者均出现不良反应症状,观察组的发生率更低,差异有统计学意义(P<0.05)。结论采用前列地尔联合异丙嗪治疗急诊眩晕的总体优势显著,可有效改善患者的凝血功能,且用药安全性高。Objective To study the overall effect of alprostadil combined with promethazine in the treatment of patients with emergency vertigo,focusing on evaluating the efficacy and safety of the combination of the two drugs.Methods A total of 104 emergency vertigo patients admitted to the hospital from January to December 2019 were conveniently selected as the research objects,and they were divided into groups by random number table,52 cases in each group.Patients in the control group were treated with alprostadil,and patients in the observation group were treated with prostadil on the basis of alprostadil.Compared the similarities and differences of the effects of the two treatment programs on clinical efficacy and drug safety.Results The total effective rate of the observation group was 96.15%,which was significantly higher than 84.62%of the control group,and the difference was statistically significant(χ^(2)=3.983,P<0.05);after treatment,the coagulation function indexes of the two groups were changed compared with those before treatment.The observation group was longer than that of the control group,and the difference was statistically significant(P<0.05).The fibrinogen of the two groups after treatment was lower than that before treatment,and the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05);after treatment,the blood routine of the two groups were improved compared with those before treatment,and the indexes of the observation group were better than those of the control group,and the difference was statistically significant(P<0.05);during the treatment,the patients in the observation group and the control group had adverse reaction symptoms,and the incidence in the observation group was lower,the difference was statistically significant(P<0.05).Conclusion The overall advantages of using alprostadil combined with promethazine in the treatment of emergency vertigo are significant,which can effectively improve the coagulation function of patients,and

关 键 词：前列地尔 异丙嗪 急诊眩晕 凝血功能 临床疗效 安全性 

分 类 号：R4[医药卫生—临床医学]