Polarized hydroxyapatite/BaTiO_(3) scaffolds with bio-inspired porous structure for enhanced bone penetration  

作　　者：Chun-Sheng Shao Liang-Jian Chen Rui-Min Tang Bo Zhang Jiang-Jie Tang Wei-Na Ma 

机构地区：[1]Department of Stomatology,Third Xiangya Hospital,Central South University,Changsha 410013,China

出　　处：《Rare Metals》2022年第1期67-77,共11页稀有金属（英文版）

基　　金：This study was financially supported by the National Natural Science Foundation of China(Nos.81571021 and 51072235).

摘　　要：The porous HA/BaTiO_(3)ceramics have the potential to exhibit superior capabilities to promote bone in-growth.However,there are few reports on in vivo studies.Here,we fabricated bio-inspired porous HA/BaTiO_(3)composites for bone repair via freeze-casting.These composites had a unique microstructure composed of the central canal and radically distributed lamellae,similar to the structure of nature cortical bone unite,the Haversian system.Polarized and non-polarized bio-inspired porous HA/BaTiO_(3)samples were implanted into the femoral condyle of the New Zealand rabbits.It was demonstrated that the polarization of the porous HA/BaTiO_(3)played a favorable part in bone regeneration.Moreover,the combination between the osteoconductivity of the microstructure and augmented osteogenic cell behavior induced by charges on surfaces of polarized porous HA/BaTiO_(3)facilitated bone penetration through the implants.The bio-inspired porous HA/BaTiO_(3)composites are demonstrated to be promising scaffolds for bone repair.

关 键 词：Porous materials Freeze-casting HYDROXYAPATITE BaTiO_(3) Bone regeneration 

分 类 号：R318.08[医药卫生—生物医学工程] TB332[医药卫生—基础医学]