In vitro and in vivo antibacterial activity of graphene oxidemodified porous TiO_(2) coatings under 808-nm light irradiation  

作　　者：Mao-Zhou Chai Mei-Wen An Xiang-Yu Zhang Paul-KChu 

机构地区：[1]College of Biomedical Engineering,Taiyuan University of Technology,Taiyuan 030024,China [2]Laboratory of Biomaterial Surfaces&Interfaces,Institute of New Carbon Materials,Taiyuan University of Technology,Taiyuan 030024,China [3]Shanxi Key Laboratory of Bone and Soft Tissue Injury Repair,Department of Orthopedics,Second Hospital of Shanxi Medical University,Taiyuan 030024,China [4]Department of Physics,Department of Materials Science and Engineering,and Department of Biomedical Engineering,City University of Hong Kong,Kowloon,Hong Kong 999077,China

出　　处：《Rare Metals》2022年第2期540-545,共6页稀有金属（英文版）

基　　金：This work was financially supported by the National Natural Science Foundation of China(No.31870934);the Major Projects in Research and Development of Shanxi(No.201803D421090);City University of Hong Kong Strategic Research Grant(No.7005264);Guangdong-Hong Kong Technology Cooperation Funding Scheme GHP/085/18SZ(No.CityU 9440230)。

摘　　要：Bio-inertness and post-surgery infection on titanium(Ti)are the main causes of failure of biomedical implants in vivo.Near-infrared(NIR)photoactivated antibacterial therapy including photothermal and photodynamic therapies has attracted increasing attention due to the high bactericidal efficiency and little side effects.Although micro-arc oxidation(MAO)is an effective method to improve the biological activity of Ti implants,the porous TiO_(2)coatings prepared by MAO do not respond to near-infrared(NIR)light to kill bacteria by the photothermal and photodynamic effects.In this work,graphene oxide(GO)-modified TiO_(2)coatings(TiO_(2)/GO)are prepared on Ti to improve the photothermal and photodynamic ability of the MAO coatings.The TiO_(2)/GO coatings exhibit excellent antibacterial activity both in vitro and in vivo against Streptococcus mutans(S.mutans)under 808-nm NIR light irradiation due to the synergistic effects rendered by hyperthermia and reactive oxygen species(ROS).The NIR light-responsive antibacterial MAO coatings have large potential in combating implant-associated infections in clinical applications.

关 键 词：Antibacterial activity Graphene oxide(GO) Porous TiO_(2)coating Photo-therapy 

分 类 号：R318[医药卫生—生物医学工程] TG178[医药卫生—基础医学]