Surface modification of titanium implants with micro–nanotopography and NIR photothermal property for treating bacterial infection and promoting osseointegration  

作　　者：Yao Ding Zhang Yuan Jin-Wei Hu Kun Xu Hong Wang Peng Liu Kai-Yong Cai 

机构地区：[1]Key Laboratory of Biorheological Science and Technology,Ministry of Education College of Bioengineering,Chongqing University,Chongqing 400044,China [2]Teaching Affairs Department,Chongqing Normal University,Chongqing 401331,China

出　　处：《Rare Metals》2022年第2期673-688,共16页稀有金属（英文版）

基　　金：This work was financially supported by the State Key Project of Research and Development(Nos.2016YFC1100300 and 2017YFB0702603);the National Natural Science Foundation of China(Nos.51825302,21734002 and 51673032).The Analytical and Testing Center of Chongqing University is greatly acknowledged for the help with the characterization of materials.

摘　　要：A double acid corrosion and subsequent hydrothermal treatment were used to fabricate a micro–nano-structured Ti substrates(Ti–M–N).Afterward,the mesoporous polydopamine(MPDA)nanoparticles as photothermal agent were prepared and immobilized on the surface of Ti–M–N samples,in order to obtain Ti–M–NMPDA sample.Unique micro–nanostructure properties and the photothermal effect of the modified Ti implant caused physical stress on the bacteria and the bacterial membrane damage,and eventually led to bacteria death.More importantly,based on excellent bioactivity and cytocompatibility of mussel-inspired materials,MPDA promoted adhesion,proliferation and osteogenic differentiation of mesenchymal stem cells in vitro.Furthermore,animal experiments in vivo further confirmed that the modified Ti implants could enhance osseointegration.

关 键 词：Titanium implants Bacterial infection OSSEOINTEGRATION Photothermal therapy Micro–nanotopography 

分 类 号：R318.08[医药卫生—生物医学工程] TG178[医药卫生—基础医学]