Zwitterionic-phosphonate block polymer as anti-fouling coating for biomedical metals  

作　　者：Ya-Hui Gu Hong-Wei Liu Xiao-Han Dong Zhuang-Zhuang Ma You-Xin Li Li Li Dong-Lin Gan Ping-Sheng Liu Jian Shen 

机构地区：[1]Jiangsu Key Laboratory of Bio-Functional Materials,Jiangsu Collaborative Innovation Center of Biomedical Functional Materials,School of Chemistry and Materials Science,Nanjing Normal University,Nanjing 210023,China [2]Jiangsu Engineering Research Center of Interfacial Chemistry,Nanjing University,Nanjing 210093,China

出　　处：《Rare Metals》2022年第2期700-712,共13页稀有金属（英文版）

基　　金：This work was financially supported by the Six Talent Peaks Project in Jiangsu Province(No.SWYY-060);the National Natural Science Foundation of China(No.21504046);the Projects of Nanjing Normal University(Nos.184080H20192,184080H10386 and 184080H202B283).

摘　　要：Antifouling ability and blood compatibility are critically important in the development of medical metallic implants for clinical applications.Here,we report the zwitterionic-phosphonate block polymer as a new type of high-efficiency antifouling coating for metallic substrates.Six block polymers(pSBMA-b-pDEMMP)with different segment lengths(nSBMA:nDEMMP=10:25,40:25,100:25,75:5,75:40,75:100)were prepared and anchored on titanium alloy(TC4)substrates.1H nuclear magnetic resonance(NMR)results clearly showed the precise preparation of the block polymers.XPS analysis and water contact angle measurement indicated the successful construction of the block polymer on TC4 substrates.The relationship between the antifouling performance of the polymer coating and the length of pDEMMP and pSBMA segments in the block polymer was established.Results showed that the polymer containing the pSBMA segment above 40 repeat units could significantly inhibit protein adsorption,platelet adhesion,bacterial adhesion and cell adhesion,while the pDEMMP segment above 5 repeat units is able to generate stable zwitterionic polymer coating on TC4 substrates.This ease of production and high-efficiency antifouling modification strategy elucidated here may find broad application for biomedical implants and devices in clinical applications.

关 键 词：ZWITTERIONIC PHOSPHONATE Anti-fouling coating Biomedical metals 

分 类 号：R318.08[医药卫生—生物医学工程] TG174.4[医药卫生—基础医学]