慢性阻塞性肺疾病急性加重期呼吸道病毒感染情况与相关危险因素分析  

Analysis of Respiratory Virus Infection and Related Risk Factors in Acute Exacerbation of Chronic Obstructive Pulmonary Disease

作　　者：王二雄 白晓兵[1] 白芳芳 李丹 李姗 李莉[1] WANG Erxiong;BAI Xiaobing;BAI Fangfang;LI Dan;LI Shan;LI Li(Department of Respiratory and Critical Care Medicine,Yulin First Hospital,Yulin,Shaanxi Province,719000 China;School of Medicine,Yan'an University,Yan'an,Shaanxi Province,716000 China)

机构地区：[1]榆林市第一医院呼吸与危重症医学科,陕西榆林719000 [2]延安大学医学院,陕西延安716000

出　　处：《系统医学》2022年第1期31-34,共4页Systems Medicine

基　　金：榆林市科技计划项目(YF-2020-043)。

摘　　要：目的通过对慢性阻塞性肺疾病急性加重(AECOPD)患者痰标本检测,指导病毒感染状况并进行观察探讨。方法选取2019年12月—2020年7月于该院呼吸内科住院的66例AECOPD患者,收集入院后治疗前痰液标本,利用Q-PCR技术进行10联常见呼吸道病毒核酸检测,参考痰液分析报告,把该次研究病例划为阳性组(32例)和阴性组(34例),同时利用CRF表记录患者一般临床资料,用于分析AECOPD患者病毒感染相关因素。结果该次检出病毒主要有EB病毒,占检出病毒的78.1%;其次为A流感型病毒和单纯疱疹病毒,各占检出病毒的12.5%;呼吸道合胞病毒及巨细胞病毒各占检出病毒的9.4%;有7例为双重感染。多因素Logistic回归分析结果为发热、白细胞数降低与慢性阻塞性肺疾病急性加重病毒感染有相关性(P<0.05)。结论AECOPD患者呼吸道病毒检测阳性率较高,提示病毒感染可能为AECOPD主要原因之一。发热、白细胞数减少预示有病毒感染。Objective Through the detection of sputum samples of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD),to guide and observe the status of virus infection.Methods Sixty-six AECOPD patients who were hospitalized in the Department of Respiratory Medicine of the hospital from December 2019 to July 2020 were selected to collect sputum samples before treatment after admission.Used Q-PCR technology to carry out 10 common respiratory virus nucleic acid tests,referring to the sputum analysis report,the study cases were divided into positive group(32 cases)and negative group(34 cases).At the same time,the CRF table was used to record the general clinical data of patients,which was used to analyze the related factors of viral infection in AECOPD patients.Results The viruses detected this time were mainly Epstein-Barr virus,accounting for 78.1%of the detected viruses.Followed by influenza A virus and herpes simplex virus,each accounted for 12.5%of the detected viruses,respiratory syncytial virus and cytomegalovirus each accounted for 9.4%of the detected viruses.There were 7 cases of double infection.The results of multivariate logistic regression analysis were fever,white blood cell count reduction were related to acute exacerbation of chronic obstructive pulmonary disease with viral infection(P<0.05).Conclusion The positive rate of respiratory virus detection in AECOPD patients is relatively high,which suggests that viral infection may be one of the main reasons for AECOPD.Fever and decreased white blood cell count indicate viral infection.

关 键 词：慢性阻塞性肺疾病 急性加重 呼吸道病毒感染 

分 类 号：R59[医药卫生—内科学]