丙氨酸-谷氨酰胺肠外营养支持治疗慢性阻塞性肺病急性加重期合并Ⅱ型呼吸衰竭患者的临床疗效探讨  

The Clinical Effect of Alanine-glutamine Parenteral Nutrition Support in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease Patients with TypeⅡRespiratory Failure

作　　者：方伟 董扬 FANG Wei;DONG Yang(Department of Respiratory Medicine,Nan'an District People's Hospital,Chongqing,400060 China)

机构地区：[1]重庆市南岸区人民医院呼吸内科,重庆400060

出　　处：《系统医学》2022年第1期89-92,101,共5页Systems Medicine

摘　　要：目的研究丙氨酸-谷氨酰胺肠外营养支持治疗慢性阻塞性肺病急性加重期合并Ⅱ型呼吸衰竭患者的临床疗效。方法该研究选择的60例研究对象均来源于2018年1月—2020年1月重庆市南岸区人民医院收治的慢性阻塞性肺病急性加重期合并Ⅱ型呼吸衰竭患者,按照随机数表法分组,分别为观察组和对照组,各30例。通过静脉滴注复方氨基酸治疗的患者为对照组,在此基础上,联合静脉滴注丙氨酸-谷氨酰胺进行肠外营养支持的患者为观察组,比较两组患者的治疗效果。结果治疗前,两组患者的各项临床指标比较,差异无统计学意义(P>0.05);治疗后,观察组患者的第一秒用力呼气容积(FEV1)、第1秒用力呼气的容积占预计值的百分比(FEV1%pred)分别为(1.36±0.15)L、(48.15±4.16)%,均优于对照组,差异有统计学意义(P<0.05)。观察组患者的营养指标、动脉血气指标均优于对照组患者,差异有统计学意义(P<0.05)。观察组患者的生活质量以及呼吸水平均优于对照组患者,差异有统计学意义(P<0.05)。观察组患者的机械通气时间以及住院时间分别为(6.54±1.46)、(8.34±1.92)d,均短于对照组患者,差异有统计学意义(t=2.817、2.102,P<0.05)。结论慢性阻塞性肺病急性加重期合并Ⅱ型呼吸衰竭患者通过丙氨酸-谷氨酰胺肠外营养支持治疗,能够有效改善患者的肺功能、营养情况、生活质量,减少住院时间,促进康复,应用价值高。Objective To study the clinical efficacy of alanine-glutamine parenteral nutrition support in the treatment of patients with acute exacerbation of chronic obstructive pulmonary disease and typeⅡrespiratory failure.Methods The 60 research subjects selected by the authors of this study were all from patients with chronic obstructive pulmonary disease who were admitted to the Nan'an District People's Hospital in Chongqing from January 2018 to January 2020 with acute exacerbation of chronic obstructive pulmonary disease and typeⅡrespiratory failure.After the samples were selected,they were grouped into the observation group and control group according to the random number table method,each group consisted of 30 patients.The patients treated by intravenous infusion of compound amino acids were the control group.On this basis,the patients who received combined intravenous infusion of alanine-glutamine for parenteral nutrition support were the observation group.The treatment effects of the two groups were compared.Results The clinical indicators of the two groups of patients before treatment were compared,and the difference was not statistically significant(P>0.05).After treatment,the forced expiratory volume in the first second(FEV1)and the percentage of forced expiratory volume in the first second in the expected value(FEV1%PRED)the observation group were(1.36±0.15)L,(48.15±4.16)%,which were better than the control group,the difference was statistically significant(P<0.05).The nutritional indicators,and arterial blood gas indicators of the observation group were better than those of the control group,and the difference was statistically significant(P<0.05).The quality of life and respiratory level of patients in the observation group were better than those in the control group,and the difference was statistically significant(P<0.05).The mechanical ventilation time and hospitalization time of the observation group were(6.54±1.46)d and(8.34±1.92)d,which were shorter than those of the control group,and the differ

关 键 词：丙氨酸-谷氨酰胺 肠外营养支持 慢性阻塞性肺疾病急性加重期 Ⅱ型呼吸衰竭 

分 类 号：R563[医药卫生—呼吸系统]