瑞芬太尼对女性晕动病患者术后恶心呕吐的影响  

Effects of remifentanil on postoperative nausea and vomiting in female patients with motion sickness

作　　者：吴海星 李粮辉 陈婷[1] 陈佳莉 吴思惠 Wu Haixing;Li Lianghui;Chen Ting;Chen Jiali;Wu Sihui(Department of anesthesiology,Fujian provincial Jinshan hospital,provincial clinical college of Fujian Medical University,Fuzhou,Fujian,350028,China.)

机构地区：[1]福建省立金山医院麻醉科,福建医科大学省立临床医学院,福建福州350028

出　　处：《齐齐哈尔医学院学报》2022年第2期152-157,共6页Journal of Qiqihar Medical University

摘　　要：目的探讨瑞芬太尼对女性晕动病患者术后恶心呕吐的影响。方法选择2019年9月—2020年12月本院收治的有晕动病病史拟行择期无痛胃镜检查的患者(美国麻醉协会(ASA)Ⅰ-Ⅱ级、年龄20-50岁、体重指数18-30 kg/m2)120例纳入研究,随机数表法分为丙泊酚+瑞芬太尼组(PR组)、丙泊酚+舒芬太尼组(PS组)和丙泊酚组(P组)共三组,每组各40例。主要观察指标为术后24 h PONV情况;次要观察指标为患者离开PACU时眩晕情况、丙泊酚总用量、恢复时间及患者满意度。结果最终有116例患者纳入统计分析,PR组38例,PS组39例,P组39例。术后24 h PONV发生情况:三组间差异具有统计学意义(P<0.05);PS组发生情况明显高于PR组和P组,差异有统计学意义(P<0.05);PR组和P组两组间差异无统计学意义(P>0.05);丙泊酚总用量比较:P组丙泊总酚用量最大,P组分别和PR、PS组比较,差异有统计学意义(P<0.05);PR组用量次之,与PS组比较,差异有统计学意义(P<0.05);恢复时间:P组恢复时间明显长于PR、PS组,差异有统计学意义(P<0.05),而PR组和PS组两组之间则差异无统计学意义(P>0.05);患者离开PACU时眩晕情况:PS组明显高于PR组和P组,差异有统计学意义(P<0.05),PR和P组两组之间差异无统计学意义(P>0.05);满意度比较:PS组满意度明显低于PR组和P组,差异有统计学意义(P<0.05),PR和P组两组之间差异无统计学意义(P>0.05)。结论女性晕动病患者行门诊胃肠镜检查时选择丙泊酚复合0.5μg/kg瑞芬太尼安全、有效,并能有效降低患者PONV,提高患者满意度,值得在临床推广应用。Objective To investigate the effect of remifentanil on postoperative nausea and vomiting in female patients with motion sickness.Methods Totally 120 patients(American Society of Anesthesiologists,ASA,class I to II;aged from 20 to 50 years old;body mass index between 18 and 30 kg/m2)had the history of motion sickness and scheduled for painless gastroscopy in our hospital during September 2019 and December 2020 were enrolled in the study.They were divided randomly into three group according to random number table method:propofol+remifentanil group(group PR),propofol+sufentanil group(group PS)and propofol group(group P),with 40 patients each.The main observation indicators was the degree and incidence of PONV within 24 h after painless gastroscopy.Secondary outcome measures were vertigo at their discharge from PACU,total dosage of propofol,recovery time,and patient satisfaction.Results One hundred and sixteen patients were included in the study,there were 38 cases in PR group,39 cases in PS group,and 39 cases in P group.The incidence of PONV among the three groups were statistically significant(P<0.05).The incidence of PONV in group PS was significantly higher than that in group PR and group P(P<0.05),however,there was no significant difference in incidence of PONV between group PR and P(P>0.05).The total dosage of propofol in group P was the largest,and there were significant differences between group P and group PR and PS(P<0.05).The total dosage of propofol in group PR was significantly larger than group PS(P<0.05).The recovery time of group P was longer than that of group PR and PS(P<0.05),but there was no significant difference between group PR and PS(P>0.05).The incidence of vertigo of patients in group PS was significantly higher than that in group PR and group P when they leaving PACU(P<0.05),but there was no significant difference between group PR and P(P>0.05).The lowest satisfaction was observed in the group PS with the whole process(P<0.05);however,there was no significant difference between group PR and

关 键 词：瑞芬太尼 丙泊酚 女性 晕动病 术后恶心呕吐 

分 类 号：R653[医药卫生—外科学]