点击化学法合成柚皮素1,2,3-三氮唑衍生物  

Synthesis of Naringenin Containing 1,2,3-Triazole Derivatives via Click Chemistry

作　　者：庞杰 袁海燕 刘志平 黄燕敏 展军颜 PANG Jie;YUAN Hai-yan;LIU Zhi-ping;HUANG Yan-min;ZHAN Jun-yan(Chemistry and Material Sciences,Nanning Normal University,Nanning 530001,China;College of Pharmacy,Guangxi Medical University,Nanning 530021,China)

机构地区：[1]南宁师范大学化学与材料学院,广西南宁530001 [2]广西医科大学药学院,广西南宁530021

出　　处：《南宁师范大学学报（自然科学版）》2021年第4期91-95,共5页Journal of Nanning Normal University：Natural Science Edition

基　　金：广西自然科学基金(2020GXNSFAA159096,2014GXNSFBA118033);广西创新发展专项项目(AA18242027)。

摘　　要：点击化学是一种高效合成1,2,3-三氮唑的方法,在药物设计及合成中得到广泛应用。该研究通过酸水解柚皮苷、与溴丙炔醚化等方法合成了柚皮素含炔化合物,然后与苄基叠氮化物或乙酸乙酯叠氮化物应用点击化学法高效合成了7个含1,2,3-三氮唑结构的柚皮素衍生物,并通过核磁共振及高分辨质谱进行了结构表征。Click chemistry is an efficient method for the synthesis of 1,2,3-triazole,playing an important role in drug design and synthesis.In this paper,naringenin containing alkyne were synthesized by acid hydrolysis of naringin and etherification with bromopropyne.Then seven naringenin derivatives containing 1,2,3-triazole structure were synthesized by click chemistry with benzyl azide or ethyl acetate azide,and their structures were characterized by NMR and HR-MS spectrometry.

关 键 词：柚皮素 1 2 3-三氮唑 点击化学法 

分 类 号：TQ252.6[化学工程—有机化工]