α1-抗胰凝乳蛋白酶多态性与慢性阻塞性肺疾病易感性的关系  

Association between polymorphism ofα1-antichymotrypsin and susceptibility to COPD

作　　者：尹迎秋[1] 韦杰[1] 郑惠英[1] YIN Ying-qiu;WEI Jie;ZHENG Hui-ying(Respiratory Department of the People's Hospital of North,Shaoguan 512026,China)

机构地区：[1]粤北人民医院呼吸内科,广东韶关512026

出　　处：《吉林医学》2022年第3期620-622,共3页Jilin Medical Journal

摘　　要：目的:探讨α1-抗胰凝乳蛋白酶(α1-AT)多态性与慢性阻塞性肺疾病(COPD)易感性的关系。方法:选取收治的COPD患者110例(COPD组),同时选取健康志愿者110例作为对照组,采用PCR-限制性片段长度多态性方法检测α1-AT基因rs1243166序列基因多态性。结果:COPD组和对照组α1-AT基因rs1243166序列基因型分布比较差异有统计学意义(P<0.05),其中COPD组基因型GG和等位基因G比例分别为38.18%和60.00%,高于对照组;GG型患者一秒用力呼气量占用力肺活量比值(FEV_(1)/FVC)为(48.89±9.92)%,明显低于AA型和GA型患者,差异有统计学意义(P<0.05);AA型和GA型患者FEV_(1)/FVC比较差异无统计学意义(P>0.05)。结论:α1-AT基因rs1243166序列基因多态性与COPD易感性有关,基因型GG患者肺功能较差。Objective To explore the relationship between the polymorphism ofα1-antichymotrypsin(α1-AT)and the susceptibility of chronic obstructive pulmonary disease(COPD).Method 110 COPD patients(COPD group)treated in our hospital were selected,and 110 healthy volunteers were selected as control group,the rs1243166 gene polymorphism ofα1-AT gene was detected by PCR-restriction fragment length polymorphism.Results There was significant difference in genotype distribution of rs1243166 sequence between COPD group and control group(P<0.05),the proportion of genotype GG and allele G in COPD group were 38.18%and 60.00%,respectively,which were higher than that in control group;The ratio of forced expiratory volume persecond to forced vital capacity(FEV_(1)/FVC)in GG patients was(48.89±9.92)%,which were significantly lower than that in AA and GA patients(P<0.05);There were no significant difference in FEV_(1)/FVC between AA and GA patients(P>0.05).Conclusion The rs1243166 gene polymorphism ofα1-AT gene is related to the susceptibility of COPD,and the lung function of GG patients is poor.

关 键 词：α1-抗胰凝乳蛋白酶 慢性阻塞性肺疾病 rs1243166序列 易感性 

分 类 号：R563.9[医药卫生—呼吸系统]