中性粒细胞/淋巴细胞比值与阻塞性睡眠呼吸暂停的相关性研究  

Study on the correlation between neutrophil-to-lymphocyte ratio and OSA

作　　者：杨军 谢宇平[3] 周丽雅[4] 柳小平[1] 惠培林 马薇[3] 马雪萍[1] 苏晓艳 YANG Jun;XIE Yuping;ZHOU Liya;LIU Xiaoping;HUI Peilin;MA Wei;MA Xueping;SU Xiaoyan(Second People's Hospital of Gansu Province,Lanzhou,Gansu,730000,China;Gansu University of Traditional Chinese Medicine,Lanzhou,Gansu,730000,China;Department of Sleep Medicine Center,Gansu Provincial Hospital,Lanzhou,Gansu,730000,China;Department of Neurophysiology,Gansu Provincial Hospital,Lanzhou,Gansu,730000,China)

机构地区：[1]甘肃省第二人民医院,甘肃兰州730000 [2]甘肃中医药大学,甘肃兰州730000 [3]甘肃省人民医院睡眠医学中心,甘肃兰州730000 [4]甘肃省人民医院神经电生理室,甘肃兰州730000

出　　处：《中国耳鼻咽喉头颈外科》2022年第1期6-9,共4页Chinese Archives of Otolaryngology-Head and Neck Surgery

基　　金：国家自然科学基金地区科学基金(82160267);中央引导地方科技发展专项(甘科资函[2020]60号);甘肃省科技计划项目任务书(20JR10RA437);甘肃省科技计划项目任务书(21YF5FA020);甘肃省人民医院院内基金项目(2019-264)。

摘　　要：目的探讨中性粒细胞与淋巴细胞比值(neutrophil-to-lymphocyte ratio,NLR)与阻塞性睡眠呼吸暂停(OSA)的相关性。方法回顾性分析2019年7月~2020年6月就诊于甘肃省人民医院睡眠医学中心的OSA患者120例和非OSA患者60例,查阅其病程记录及相关检查。采用Pearson相关检验分析NLR与呼吸暂停低通气指数(AHI)和最低血氧饱和度(LSaO_(2))的相关性,采用Logistic回归分析OSA的独立危险因素,以受试者工作特性(ROC)曲线分析NLR预测OSA的最佳临界值。结果OSA组中BMI、NLR、白细胞计数(WBC)、C-反应蛋白(CRP)、甘油三脂(TG)和高密度脂蛋白胆固醇(HDL-C)均高于对照组(P均<0.05);OSA患者中NLR与AHI正相关(r=0.2187,P=0.016),与LSaO_(2)负相关(r=-0.1863,P=0.0416);BMI(OR=1.52,P=0.000)和NLR(OR=2.282,P=0.023)是OSA的独立危险因素。ROC曲线分析显示NLR最佳临界值为2.105时特异性为78.3%,敏感性为49.2%。结论NLR与OSA患者病情程度呈正相关,具有一定的临床价值。OBJECTIVE To explore the correlation between neutrophil-to-lymphocyte ratio(NLR) and OSA.METHODS We retrospectively analyzed the clinical data of 120 OSA patients and 60 non-OSA patients(control group) who were admitted to Sleep Medicine Center of People’s Hospital of Gansu Povince from July 2019 to June 2020.Pearson correlation test was used to analyze the correlation between apnea hypoventilation index(AHI),lowest oxygen saturation(LSaO_(2)) and NLR.Logistic regression was used to analyze the independent risk factors of OSA,and the receiver operating characteristic(ROC) curve was used to analyze the optimal cut-off value of NLR to predict OSA.RESULTS In the OSA group,BMI,NLR,white blood cell count(WBC),C-reactive protein(CRP) and high density lipoprotein cholesterol(HDL-C) were all higher than those in the control group(all P<0.05).In OSA patients,NLR was positively correlated with AHI(r=0.2187,P=0.016) and negatively correlated with LSaO_(2)(r=-0.1863,P=0.0416).NLR(OR=2.282,P=0.023) and BMI(OR=1.52,P=0.000) were independent predictors of OSA.ROC curve analysis verified that the optimal cut-off value of NLR was 2.105,and the specificity was 78.3% and sensitivity was 49.2%.CONCLUSION NLR is positively correlated with the severity of OSA patients and has certain clinical value.

关 键 词：睡眠呼吸暂停 阻塞性 炎症 回归分析 中性粒细胞与淋巴细胞比值 

分 类 号：R766[医药卫生—耳鼻咽喉科]