左甲状腺素钠片致药物热  

Drug fever caused by levothyroxine sodium tablets

作　　者：于丽萍 彭相君 陈杰[2] 王萍 张传洲[2] Yu Liping;Peng Xiangjun;Chen Jie;Wang Ping;Zhang Chuanzhou(Department of Pharmacy,the Second People′s Hospital of Rizhao,Shandong Province,Rizhao 276807,China;Deptartment of Pharmacy,the Affiliated Hospital of Qingdao University,Shandong Province,Qingdao 266555,China;Department of Pharmacy,People′s Hospital of Jiaozhou,Shandong Province,Jiaozhou 266300,China)

机构地区：[1]山东省日照市第二人民医院药学部,日照276807 [2]青岛大学附属医院药学部,青岛266555 [3]山东省胶州市人民医院药学部,胶州266300

出　　处：《药物不良反应杂志》2022年第2期92-93,共2页Adverse Drug Reactions Journal

摘　　要：1例75岁女性患者因甲状腺恶性肿瘤行甲状腺全切除术+颈部淋巴结清扫术,术后为补充甲状腺激素,给予左甲状腺素钠片100μg鼻饲、1次/d。用药第5天患者出现发热,体温最高39.0℃;停用左甲状腺素钠片,次日体温下降至36.2℃;再次鼻饲左甲状腺素钠片或口服其他厂家生产的左甲状腺素钠片,用药后均出现发热,停药后体温均恢复正常。考虑患者的发热为左甲状腺素钠片所致药物热。A 75‑year‑old female patient underwent total thyroidectomy and neck lymph node dissection for thyroid malignant tumor.In order to supplement thyroid hormone after operation,the patient was given levothyroxine sodium tablets 100μg by nasal feeding once daily.On the 5th day of treatment,the patient developed fever,with highest body temperature 39.0℃.The levothyroxine sodium were stopped,then her body temperature decreased to 36.2℃the following day.After giving nasal feeding of levothyroxine sodium tablets again or oral levothyroxine sodium tablets produced by other manufacturers,fever recurred in the patient and the body temperature returned to normal after drug withdrawal.It was considered that the patient′s fever was drug fever caused by levothyroxine sodium tablets.

关 键 词：发热 药物相关副作用和不良反应 左甲状腺素钠 

分 类 号：R969.3[医药卫生—药理学]