质谱流式细胞术:急性髓系白血病精准诊疗的新热点  

Mass cytometry: a new hot spot for accurate diagnosis and treatment of acute myeloid leukemia

作　　者：郭元成 刘蓓[1,2] Guo Yuan-cheng;Liu Bei(The First School of Clinical Medicine,Lanzhou University,Lanzhou 730000,China;Department of Hematology,The First Hospital of Lanzhou University,Lanzhou 730000,China)

机构地区：[1]兰州大学第一临床医学院,甘肃兰州730000 [2]兰州大学第一医院血液科,甘肃兰州730000

出　　处：《兰州大学学报（医学版）》2022年第1期81-84,共4页Journal of Lanzhou University（Medical Sciences）

基　　金：甘肃省自然科学基金资助项目(18JR3RA356)。

摘　　要：质谱流式细胞术是一种将传统流式细胞技术与质谱技术相结合的新技术,拥有高通量、金属标签以及条形码等多个优势,可精细分析急性髓系白血病(AML)细胞群体表型、细胞周期和信号通路,在鉴定治疗靶标、研发靶向药物以及动态监测治疗过程等领域有广泛的应用前景。本研究综述对质谱流式细胞仪的工作原理、技术优势及其在AML精准诊疗中的应用。Mass cytometry is a new technology combining traditional flow cytometry with mass spectrometry,which has several advantages such as high throughput,metal labeling and barcoding,can provide fine analysis of acute myelogenous leukemia(AML)cell population phenotype,cell cycle and signaling pathways,has a wide application prospect in the fields of identifying therapeutic targets,developing targeted drugs and dynamically monitoring the treatment process.In this paper,we review the working principles and technical advantages of mass cytometry and its application in AML precision diagnosis and treatment.

关 键 词：质谱流式细胞术 精准诊疗 急性髓系白血病 

分 类 号：R551[医药卫生—血液循环系统疾病]