Aurora激酶A调控卵母细胞减数分裂的分子机制  

Molecular Mechanism of Aurora Kinase A Regulating the Meiosis of Oocyte

作　　者：刘凤 姚波 莫晓龙 柳琼友 任艳萍 LIU Feng;YAO Bo;MO Xiaolong;LIU Qiongyou;REN Yanping(Department of Histology and Embryology,School of Preclinical Medicine,Zunyi Medical University,Zunyi,Guizhou 563000,China)

机构地区：[1]遵义医科大学基础医学院组织胚胎学教研室,贵州遵义563000

出　　处：《中国医学科学院学报》2022年第1期142-148,共7页Acta Academiae Medicinae Sinicae

基　　金：国家自然科学基金项目(31860329);贵州省科技厅项目[黔科合基础(2019)1344号];贵州省教育厅科技青年人才成长项目[黔教合KY字(2017)183];遵义市“15851人才精英工程”。

摘　　要：Aurora激酶A(AURKA)是Aurora激酶家族成员,其参与有丝分裂进入、中心体成熟和分离、双极纺锤体组装和稳定以及染色体的凝集和分离。AURKA在减数分裂过程中发挥的作用与有丝分裂类似,但其具体作用机制以及其与有丝分裂的异同尚不清楚。因此本文从AURKA在卵母细胞减数分裂中的定位与活化,及其在调控纺锤体形成、纺锤体组装检查点活化以及动粒-微管附着纠错等方面进行综述,对比AURKA在有丝分裂和卵母细胞减数分裂中的异同,为今后进一步揭示细胞分裂调控机制以及癌症和生殖等相关临床研究奠定理论基础。Aurora kinase A(AURKA),a family member of aurora kinases,is involved in mitotic entry,maturation and separation of centrosome,assembly and stabilization of bipolar spindle,and condensation and separation of chromosome.Studies have demonstrated that AURKA plays a similar role in meiosis,while the specific mechanism and the similarities and differences in its role between meiosis and mitosis remain unclear.Therefore,we reviewed the studies about the localization and activation of AURKA in oocyte meiosis,and compared the role of AURKA in regulating spindle formation,activating spindle assembly checkpoint,and correcting the kinetochore-microtubule attachment between the meiosis of oocytes and the mitosis of somatic cells.This review will lay a theoretical foundation for revealing the mechanism of AURKA in the regulation of cell division and for the clinical research related to cancer and reproduction.

关 键 词：减数分裂 Aurora激酶A 微管组织中心 纺锤体组装 动粒-微管附着 卵母细胞 

分 类 号：R321.1[医药卫生—人体解剖和组织胚胎学]