四丁基氯化铵催化的硝基甲烷和硅基乙醛酸酯的串联反应  

n-Bu_(4)NCl Catalyzed Sequential Reaction of Nitromethane and Silyl Glyoxylates

作　　者：赵振国 朱陈 周雅楠 韩满意 ZHAO Zhenguo;ZHU Chen;ZHOU Yanan;HAN Manyi(Huaibei Longxi Biotechnology Co.,Ltd,235000,Huaibei,Anhui,China;School of Chemistry and Materials Science,Huaibei Normal University,235000,Huaibei,Anhui,China)

机构地区：[1]淮北龙溪生物科技有限公司,安徽淮北235000 [2]淮北师范大学化学与材料科学学院,安徽淮北235000

出　　处：《淮北师范大学学报（自然科学版）》2022年第1期25-30,共6页Journal of Huaibei Normal University：Natural Sciences

基　　金：安徽省大学生创新创业训练计划项目(202010373012);安徽省青年皖江学者项目(03106032);安徽高校协同创新项目(GXXT-2020-078);淮北师范大学产学研项目(22100142)。

摘　　要：为开发烯醇硅醚高效的合成方法,利用硝基烷烃和硅基乙醛酸酯的亲核加成/Brook重排/消除的串联反应过程,实现相转移条件下烯醇硅醚的合成.研究结果表明,与传统的合成方法相比,反应条件温和、操作简单,避免贵金属的使用,反应收率高,副产物较少.To develop an efficient synthesis method of silyl enol ethers,the sequential reaction of nucleophilic addition/Brook rearrangement/elimination of nitroalkanes and silyl glyoxylates has been developed under phase transfer conditions.The results showed that the reaction conditions are mild,the operation is simple,and the use of precious metals is avoided.Moreover,the reaction yield is high and there are few by-products in comparison with the traditional synthesis method.

关 键 词：相转移催化 串联反应 烯醇硅醚 

分 类 号：O643.362[理学—物理化学]