高尿酸血症与血常规指标的相关性分析  

Correlation analysis between hyperuricemia and blood routine indexes

作　　者：林燕[1] 路军梅[1] 屈鹏祥 邹雅敏[1] 樊雪英 翁改志[1] LIN Yan;LU Junmei;QU Pengxiang;ZOU Yamin;FAN Xueying;WENG Gaizhi(Clinical Laboratory Department,Xi'an Jiaotong University Hospital,Xi'an 710049;Laboratory Animal Center,Xi'an Jiaotong University Health Science Center,Xi'an 710061;Clinical Laboratory Department,Xi'an People's Hospital,Xi'an 710004,China)

机构地区：[1]西安交通大学医院检验科,陕西西安710049 [2]西安交通大学医学部实验动物中心,陕西西安710061 [3]西安市人民医院检验科,陕西西安710004

出　　处：《临床医学研究与实践》2022年第8期1-4,8,共5页Clinical Research and Practice

基　　金：陕西省创新能力支撑计划项目(No.2021PT-039)。

摘　　要：目的分析高尿酸血症(HUA)与血常规指标的相关性。方法选取2020年西安某高校参加健康体检且符合要求的4275名教职工为调查对象,收集其基本信息、血常规及血清生化指标结果并进行回顾性分析。结果4275名调查对象的平均年龄(57.19±16.61)岁;男性2049例,HUA患病率为19.47%;女性2226例,HUA患病率为16.35%。男性的血清UA水平及HUA患病率随年龄的增加而降低(P<0.05),但在65岁后趋于平稳。女性的血清UA水平及HUA患病率在45岁之前随年龄的增加逐渐降低(P<0.05),在45岁之后随年龄的增加逐渐升高。男性UA水平与年龄呈负相关,与RBC、HGB水平、WBC、PLT、PCT呈正相关(P<0.05);女性UA水平与年龄、RBC、HGB水平、WBC、PDW呈正相关,与RDW呈负相关性(P<0.05)。男性体检人群中,高UA组年龄明显低于正常UA组,RBC、HGB水平、WBC、PLT和PCT高于正常UA组(P<0.05);女性体检人群中,高UA组年龄、RBC、HGB水平、WBC均明显高于正常UA组,RDW低于正常UA组(P<0.05)。血清UA还受血脂和血糖因素影响。多因素Logistic回归分析排除干扰因素后发现,血常规中WBC和PLT越高,则人群患HUA的概率越高(P<0.05),同时,男性PDW越高,女性HGB越高,其患HUA的概率越高(P<0.05)。结论HUA与血常规中WBC、PLT、PDW及HGB指标有明显相关性,这些指标有望成为防治HUA的重要生物学指标。Objective To analyze the correlation between hyperuricemia(HUA)and blood routine indexes.Methods A total of 4275 teaching staff who participated in physical examination and met the requirements in a university in Xi'an in 2020 were selected as the survey objects.Their basic information,blood routine and serum biochemical indexes were collected and analyzed retrospectively.Results The average age of 4275 survery objects was(57.19±16.61)years old;among 2049 males,the prevalence of HUA was 19.47%;among 2226 females,the prevalence of HUA was 16.35%.The serum UA level and the prevalence of HUA in males decreased with the increase of age(P<0.05),but tended to be stable after 65 years old.The serum UA level and the prevalence of HUA in females decreased gradually with the increase of age before 45 years old(P<0.05),but increased gradually with the increase of age after 45 years old.The UA level in male was negatively correlated with age,while was positively correlated with RBC,HGB level,WBC,PLT and PCT(P<0.05);the UA level in female was positively correlated with age,RBC,HGB level,WBC and PDW,while was negatively correlated with RDW(P<0.05).In male physical examination population,the age of the high UA group was significantly lower than that of the normal UA group,while RBC,HGB level,WBC,PLT and PCT were higher than those of the normal UA group(P<0.05);in female physical examination population,the age,RBC,HGB level and WBC of the high UA group were significantly higher than those of the normal UA group,while the RDW was lower than that of the normal UA group(P<0.05).Serum UA was also affected by blood lipid and blood glucose.After excluding the interference factors,the multivariate Logistic regression analysis showed that the higher WBC and PLT in blood routine examination,the higher the risk of HUA(P<0.05);at the same time,the higher PDW in male and HGB in female,the higher the risk of HUA(P<0.05).Conclusion There is a significant correlation between HUA and WBC,PLT,PDW and HGB of blood routine.These indexes are expec

关 键 词：高尿酸血症 血常规 健康体检 

分 类 号：R589.7[医药卫生—内分泌]