吸光材料-激光解吸附离子化质谱用于化妆品中添加剂的快速分析  

Rapid Analysis of Additives in Cosmetics Using Antireflection Surfaces Laser Desorption Ionization Mass Spectrometry

作　　者：谭奥雷 马潇潇[1] TAN Ao-lei;MA Xiao-xiao(State Key Laboratory of Precision Measurement Technology and Instruments,Department of Precision Instrument,Tsinghua University,Beijing 100084,China)

机构地区：[1]清华大学精密仪器系精密测试技术及仪器国家重点实验室,北京100084

出　　处：《分析测试学报》2022年第3期381-385,共5页Journal of Instrumental Analysis

基　　金：国家重点研发计划项目(2016YFF0203704)。

摘　　要：化妆品中的添加剂种类繁多,这些物质的加入可提升化妆品的使用效果和保质期限,但过量使用则可能对人体健康造成不良影响。该研究利用吸光材料-激光解吸附离子化质谱(AR-LDI MS)建立了化妆品中添加剂的快速分析方法。利用该法对化妆品中的3-亚苄基樟脑、4-甲基苄亚基樟脑、对羟基苯乙酮和环吡酮进行检测,检出限分别为4、6、40、10 mg/kg。通过加入内标物,可实现化妆品中樟脑衍生物(3-亚苄基樟脑、4-甲基苄亚基樟脑)的定量分析,其线性范围为60~140 mg/kg。该方法前处理过程简便,总分析时间不超过5 min,分析结果灵敏、准确,在化妆品原位快检中有着较为广阔的应用前景。There are many kinds of additives in cosmetics.Addition of these substances could improve the use effect and shelf life of cosmetics, but excessive use may result adverse effects on human health.In this study,a rapid method for analysis of additives in cosmetics was established by antireflection surfaces laser desorption ionization mass spectrometry(AR-LDI MS).The detection limits for 3-benzylidene camphor, 4-methylbenzylidene camphor, p-hydroxyacetophenone and cyclopyridone in cosmetics were 4,6,40 and 10 mg/kg,respectively.The quantitative analysis of camphor derivatives including 3-benzylidene camphor and 4-methylbenzylidene camphor in cosmetics could also be realized by adding the internal standard,within linear range of 60-140 mg/kg.With simple pretreatment process,short analysis time(not more than 5 min),good sensitivity and accuracy,the method has a broad application prospect in the in-situ rapid detection of cosmetics.

关 键 词：吸光材料-激光解吸离子化质谱(AR-LDI MS) 添加剂 化妆品 快速分析 

分 类 号：O657.63[理学—分析化学] TQ047.1[理学—化学]