针灸对多发性骨髓瘤患者化疗相关周围神经病变的干预效果  

Intervention effect of acupuncture and moxibustion in treatment of chemotherapy-induced peripheral neuropathy in patients with multiple myeloma

作　　者：王磊[1] 徐晓度[1] 姚利娟[1] 黄雨婷[1] 邹璆 吴冰[1] 殷德猛 WANG Lei;XU Xiaodu;YAO Lijuan;HUANG Yuting;ZOU Qiu;WU Bing;YIN Demeng(Department of Hematology,Suzhou Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Traditional Chinese Medicine,Suzhou,Jiangsu,215009;Department of Oncological Surgery,Suzhou Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Traditional Chinese Medicine,Suzhou,Jiangsu,215009)

机构地区：[1]南京中医药大学附属苏州市中医医院血液科,江苏苏州215009 [2]南京中医药大学附属苏州市中医医院肿瘤外科,江苏苏州215009

出　　处：《实用临床医药杂志》2022年第2期28-30,共3页Journal of Clinical Medicine in Practice

基　　金：江苏省苏州市科技局基金资助项目(SYSD2018191)。

摘　　要：目的探讨针灸对化疗相关周围神经病变(CIPN)的多发性骨髓瘤(MM)患者生活质量及预后的影响。方法将符合入选标准的54例MM患者随机分为药物组28例和针灸组26例。采用肌电图(EMG)记录神经传导速度(NCV),评估治疗效果。分别记录2组患者治疗前后运动神经传导速度(MNCV)、感觉神经传导速度(SNCV)及癌症治疗功能评价系统/妇科肿瘤组-神经毒性评价工具量表(FACT/GOG-Ntx)评分。结果2组治疗后的正中神经和腓总神经MNCV与治疗前比较,差异有统计学意义(P<0.05);药物组治疗后腓浅神经SNCV与治疗前比较,差异有统计学意义(P<0.05)。治疗后,针灸组FACT/GOG-Ntx量表评分下降,差异有统计学意义(P<0.01);药物组治疗后FACT/GOG-Ntx量表评分也有所下降,但差异无统计学意义(P>0.05);2组治疗后FACT/GOG-Ntx量表评分比较,差异无统计学意义(P>0.05)。结论针灸是多发性骨髓瘤CIPN的有效干预手段之一,可提高患者的生活质量。Objective To investigate the effect of acupuncture and moxibustion on quality of life and prognosis of multiple myeloma(MM)patients with chemotherapy-related peripheral neuropathy(CIPN).Methods Fifty-four MM patients who met the inclusion criteria were randomly divided into drug group(n=28)and acupuncture and moxibustion group(n=26).Electromyography(EMG)was used to record nerve conduction velocity(NCV),and the therapeutic effect was evaluated.Motor nerve conduction velocity(MNCV),sensory nerve conduction velocity(SNCV)and Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity(FACT/GOG-Ntx)scores were recorded before and after treatment in two groups.Results MNCV of median nerve and common peroneal nerve after treatment of two groups showed a significant difference compared with that before treatment(P<0.05).The SNCV of the superficial peroneal nerve in the drug group showed a significant difference compared with that before treatment(P<0.05).After treatment,FACT/GOG-NTX score of the acupuncture and moxibustion group decreased(P<0.01).The FACT/GOG-NTX score of the drug group also decreased after treatment,but no significant difference was found(P>0.05).There was no significant difference in FACT/GOG-NTX score between the two groups after treatment(P>0.05).Conclusion Acupuncture and moxibustion is an effective therapy for treating chemotherapy-induced peripheral neuropathy and can improve patients’quality of life.

关 键 词：针灸 化疗 周围神经病变 多发性骨髓瘤 神经传导速度 

分 类 号：R552[医药卫生—血液循环系统疾病] R246[医药卫生—内科学]