平肝降压汤联合辰时百会透刺治疗1、2级原发性高血压的临床研究  

Clinical research of Pinggan Jiangya decoction combined with penetrating needling at Baihui(GV20)in a period of day from 7 am to 9 am in the treatment of grade 1 and 2 essential hypertension

作　　者：周小玲 杜艳华 陈晓辉 刘文英 黄玉梅 ZHOU Xiao-ling;DU Yan-hua;CHEN Xiao-hui;LIU Wen-ying;HUANG Yu-mei(The People’s Hospital of Longhua District,Shenzhen 518110,Guangdong Province,China)

机构地区：[1]广东省深圳市龙华区人民医院,广东深圳518110

出　　处：《针刺研究》2022年第2期165-170,共6页Acupuncture Research

摘　　要：目的:观察平肝降压汤联合辰时百会透刺治疗1、2级原发性高血压(EH)的临床疗效。方法:1、2级EH患者150例按照随机数字表法分为研究组和对照组,每组75例。对照组予以中药平肝降压汤口服,每日1剂,治疗8周;研究组予以平肝降压汤联合辰时百会透刺治疗,每次留针30 min,每日1次,每周6次,治疗8周。比较两组治疗前后中医证候评分、24 h平均收缩压(24 h ASBP)、24 h平均舒张压(24 h ADBP)、24 h平均脉压差(24 h PP)、晨峰血压(MBPS)、24 h SBP变异性(24 h SBPV)、24 h DBP变异性(24 h DBPV)、血清5-羟色胺(5-HT)和褪黑素(MT)含量的变化以及临床疗效。结果:治疗后两组头痛、眩晕、腰酸、膝软、耳鸣评分及24 h ASBP、24 h ADBP、24 h PP、MBPS、24 h SBPV、24 h DBPV均较治疗前降低(P<0.01),且研究组均低于对照组(P<0.01)。两组血清MT水平较治疗前升高(P<0.01),5-HT水平较治疗前降低(P<0.01)。研究组血清MT含量高于对照组(P<0.01),血清5-HT含量低于对照组(P<0.01)。研究组总有效率为93.3%(70/75)高于对照组的76.0%(57/75,P<0.01)。结论:平肝降压汤联合辰时百会透刺可调节血清MT、5-HT水平,有效降低血压,改善血压变异性,控制晨峰血压,治疗1、2级EH效果显著。Objective To explore the clinical effect of Pinggan Jiangya decoction combined with penetrating needling at Baihui(GV20)in a period of day from 7 am to 9 am in the treatment of grade 1 and 2 essential hypertension(EH).Methods A total of 150 cases of grade 1 and 2 EH patients were randomized into an observation group and a control group,75 cases in each group.In the control group,Pinggan Jiangya decoction was prescribed for oral administration one dose a day,while in the observation group,on the basis of the treatment as the control group,penetrating needling was exerted at GV20 once daily.The treatment duration was 8 weeks.Before and after treatment,the TCM syndrome score,24 h average systolic blood pressure(24 h ASBP),24 h average diastolic blood pressure(24 h ADBP),24 h average pulse pressure difference(24 h PP),morning blood pressure surge(MBPS),24 h SBP variability(24 h SBPV),24 h DBP variability(24 h DBPV),serum levels of 5-hydroxytryptamine(5-HT)and melatonin(MT)were compared in the patients of the two groups.The clinical therapeutic effect was observed in the two groups.Results After the treatment,in the self-comparison of each group,the scores of headache,vertigo,backache,soft knees,tinnitus,24 h ASBP,24 h ADBP,24 h PP,MBPS,24 h SBPV and 24 h DBPV in the two groups were lower than those before treatment(P<0.01),and the above indexes in the observation group were lower than those in the control group(P<0.01).The level of serum 5-HT after the treatment was lower than that of before the treatment(P<0.01),while the level of MT was higher than that of before the treatment(P<0.01)in both two groups,and the level of 5-HT in the observation group was lower than that of the control group,while the level of MT was higher than that of the control group(P<0.01).The total effective rate of the observation group was 93.3%(70/75),better than 76.0%(57/75)of the control group(P<0.01).Conclusion Pinggan Jiangya decoction combined with penetrating needling at GV20 in a period of day from 7 am to 9 am can regulate the levels

关 键 词：原发性高血压 透刺 百会 5-羟色胺 褪黑素 

分 类 号：R246.1[医药卫生—针灸推拿学]