多索茶碱联合盐酸氨溴索对老年稳定期慢阻肺患者血清IL-33/sST2轴表达的影响  

Effect of doxofylline combined with ambroxol hydrochloride on serum IL-33/sST2axis expression in elderly patients with stable chronic obstructive pulmonary disease

作　　者：张绍塘 陈伦 叶健[2] ZHANG Shao-tang;CHEN Lun;YE Jian(Respiratory Medicine,Fuyang No.2 Hospital of Hangzhou,Hangzhou 311400,Zhejiang Province,China;Respiratory Medicine,Affiliated Hangzhou First People’s Hospital Zhejiang University School of Medicine,Hangzhou 310006,Zhejiang Province,China)

机构地区：[1]杭州市富阳区第二人民医院呼吸科,浙江杭州311400 [2]浙江大学医学院附属杭州市第一人民医院呼吸科,浙江杭州310006

出　　处：《中国临床药理学杂志》2022年第4期291-295,共5页The Chinese Journal of Clinical Pharmacology

摘　　要：目的观察多索茶碱联合盐酸氨溴索对老年稳定期慢性阻塞性肺疾病(COPD)患者血清白细胞介素(IL)-33/可溶性基质裂解素2(sST2)轴表达的影响。方法将老年COPD稳定期患者126例按治疗方案的差异将其分为试验组63例及对照组63例。2组均接受常规对症支持治疗。在此基础上,对照组予以多索茶碱注射液100 mL静脉滴注治疗,bid;试验组在对照组的基础上予盐酸氨溴索注射液100 mL静脉滴注,qd,2组治疗时间均为2周。观察2组患者的临床疗效,比较治疗前后肺泡氧化功能参数、IL-33、sST2 mRNA,IL-33/sST2轴相关炎性细胞因子水平以及药物不良反应的发生情况。结果试验组和对照组的总有效率分别为93.65%(59例/63例)和77.78%(49例/63例);治疗后,试验组和对照组IL-33 mRNA分别为1.18±0.21和1.61±0.28;sST2 mRNA分别为1.12±0.24和1.34±0.24;血清IL-33分别为(386.34±28.61)和(403.70±41.26) pg·mL^(-1);血清sST2分别为(570.29±51.36)和(629.91±59.30) pg·mL^(-1),差异均有统计学意义(均P<0.05)。试验组和对照组的药物不良反应发生率分别为11.11%(7例/63例),7.94%(5例/63例),差异无统计学意义(P>0.05)。结论多索茶碱联合盐酸氨溴索能够显著抑制老年COPD稳定期患者机体内IL-33/sST2轴的活化及其下游相关炎性因子释放,进一步改善患者临床症状,促进肺泡氧合功能恢复,疗效显著,且安全性较好。Objective To observe the effect of doxofylline combined with ambroxol hydrochloride on the expression of serum interleukin (IL)-33/soluble matrix lysin 2 (sST2) axis in elderly patients with stable chronic obstructive pulmonary disease (COPD).Methods 126 elderly patients with stable COPD were divided into treatment group and control group with 63 cases according to the difference of treatment plan.Both groups received routine symptomatic and supportive treatment.On this basis,the control group was given doxofylline injection 100 mL intravenous drip,bid,and the treatment group was given doxofyl tea Alkali combined with ambroxol hydrochloride treatment,in which ambroxol hydrochloride injection 100 mL intravenously,qd,doxofylline usage and measurement are the same as the control group,the treatment time of the two groups is the same for 2 weeks.The treatment effect and related adverse reactions of the two groups were recorded,and the parameters of alveolar oxidation function,IL-33,sST2 mRNA and IL-33/sST2 axis-related inflammatory cytokine levels were measured before and after treatment,and the differences in the above indicators between the two groups were compared at the same time.Results The total effective rate of the treatment group was93.65%(59 cases/63 cases),which was higher than the control group’s 77.78%(49 cases/63 cases).After treatment,IL-33 mRNA in the treatment group and control group were 1.18±0.21,1.61±0.28;sST2 mRNA were1.12±0.24,1.34±0.24;IL-33 is (386.34±28.61),(403.70±41.26) pg·mL^(-1);sST2 is (570.29±51.36),(629.91±59.30) pg·mL^(-1),the difference was statistically significant (P<0.05).The total adverse drug reaction rates of the treatment group and the control group were 11.11%(7 cases/63 cases) and 7.94%(5 cases/63 cases),respectively,and the difference was not statistically significant (P>0.05).Conclusion Doxofylline combined with ambroxol hydrochloride can significantly inhibit the activation of IL-33/sST2 axis and the release of downstream related inflammatory factors in elderl

关 键 词：慢阻肺稳定期 多索茶碱 盐酸氨溴索 老年患者 白细胞介素-33/可溶性基质裂解素-2轴 

分 类 号：R96[医药卫生—药理学]