腹泻病患儿合并惊厥的临床特征及高危因素分析  

Clinical features and high-risk factors of children with diarrhea complicated with convulsion

作　　者：王琳[1] 王菡 刘小红[1] WANG Lin;WANG Han;LIU Xiaohong(Department of Pediatrics the First Affiliated Hospital of Xi'an Jiaotong University,Shaanxi Xi'an 710061,China;Department of Pediatrics,Xi,an Chang an District Hospital,Shaanxi Xi'an 710100,China)

机构地区：[1]西安交通大学第一附属医院儿科,陕西西安710061 [2]西安市长安区医院儿科,陕西西安710100

出　　处：《中国妇幼健康研究》2022年第1期98-103,共6页Chinese Journal of Woman and Child Health Research

摘　　要：目的探讨腹泻合并惊厥患儿的临床特征及危险因素,以提高对该种疾病的认识。方法采用病例对照研究方法,选取2008年3月至2018年2月因急性腹泻病于西安交通大学第一附属医院儿科住院的582例患儿为研究对象,以腹泻合并惊厥患儿为研究组(n=277),腹泻无惊厥患儿为对照组(n=305)。通过自行设计的调查问卷收集符合纳入标准患儿的临床资料,包括一般人口学资料、出生史、临床症状、辅助检查等,采用单因素方差分析及Logistic回归模型分析腹泻合并惊厥的危险因素。结果两组患儿性别和年龄的分布差异均有统计学意义(χ^(2)值分别为23.70、110.68,P<0.01);两组患儿喂养方式和异常出生史的分布差异均有统计学意义(χ^(2)值分别为7.23、8.12,P<0.05)。Logistic回归分析显示:女性患儿发生腹泻合并惊厥明显高于男性(P=0.01);1~<3岁患儿发生腹泻合并惊厥是0~<1岁的6.20倍(P<0.01),≥6岁患儿是0~<1岁的0.23倍(P=0.02);呕吐持续时间1天的患儿发生腹泻合并惊厥是<1天的1.86倍(P=0.03),≥3天的患儿是<1天的0.23倍(P=0.02);腹泻合并惊厥的发生与脱水程度呈反比,重度脱水患儿是未脱水的0.04倍(P=0.01);CT和磁共振成像(MRI)异常患儿发生腹泻合并惊厥的风险分别是CT和MRI正常的6.47和5.72倍(P<0.01,P=0.04)。结论女性患儿、年龄为1~<3岁、呕吐持续时间1天、轻度脱水、CT和MRI异常为患儿腹泻合并惊厥发生的危险因素。Objective To explore the clinical features and risk factors of children with diarrhea combined with convulsion, to improve the understanding of the disease.Methods Using the case-control study method, 582 children with diarrhea who were hospitalized in the department of pediatrics of the first affiliated hospital of Xi′an Jiaotong University from March 2008 to February 2018 were selected as the research objects.Children with diarrhea complicated with convulsion were regarded as the study group(n=277),and children without convulsion during the same period were regarded as the control group(n=305).Clinical data of children who met the inclusion criteria were collected through self-designed questionnaires, including demographic data, birth history, clinical symptoms and auxiliary examinations.Risk factors of diarrhea complicated with convulsion were analyzed by one-way ANOVA and Logistic regression model.Results There were significant differences in gender and age distribution between the two groups(χ^(2)=23.70 and 110.68,respectively, P<0.01).There were statistically significant differences in the distribution of feeding pattern and abnormal birth history between the two groups(χ^(2)=7.23 and 8.12,respectively, P<0.05).Logistic regression analysis showed that diarrhea complicated with convulsion was significantly higher in female than in male(P=0.01).The incidence of diarrhea complicated with convulsion in children aged 1-3 years was 6.20 times higher than that in children aged 0-1 years(P<0.01),and children aged ≥6 years was 0.23 times higher than that in children aged 0-1 years(P=0.02).The incidence of diarrhea complicated with convulsion in children with vomiting duration of 1 day was 1.86 times higher than that in children with vomiting duration less than 1 day(P=0.03),and those children with≥3 days were 0.23 times thal of less than 1 day(P=0.02).The occurrence of diarrhea complicated with convulsion was inversely proportional to the degree of dehydration, and the children with severe dehydration were 0

关 键 词：腹泻病 惊厥 危险因素 临床特征 

分 类 号：R725[医药卫生—儿科]