胰高血糖素样肽-1类似物改善肌肉萎缩的研究进展  

Research progress of glucagon-like peptide-1 analogues in ameliorating muscular atrophy

作　　者：李钰 孟怡媚 刘宽芝[1] Li Yu;Meng Yimei;Liu Kuanzhi(Department of Endocrinology and Metabolism,Third Hospital of Hebei Medical University,Shijiazhuang 050051,China)

机构地区：[1]河北医科大学第三医院内分泌与代谢科,石家庄050051

出　　处：《国际内分泌代谢杂志》2022年第1期41-44,77,共5页International Journal of Endocrinology and Metabolism

摘　　要：胰高血糖素样肽-1(GLP-1)是由肠道L细胞分泌的一种肠促胰素,其主要功能是促进胰岛素分泌和抑制胰高血糖素分泌从而降低血糖,其制剂在临床上广泛用于糖尿病的治疗。近年来有研究发现,GLP-1类似物有改善肌肉萎缩的功能,该作用与抑制肌肉生长抑制素和肌萎缩因子表达、增强肌源性因子表达、改善骨骼肌微循环和胰岛素抵抗有关。Glucagon-like peptide-1(GLP-1)is a kind of incretin secreted by intestinal L cells,whose main functions are to promote insulin secretion and inhibit glucagon secretion to reduce blood glucose.Its preparations are widely used in the treatment of diabetes mellitus.In recent years,it has been found that glucagon-like peptide-1 analogues have the function of ameliorating muscular atrophy,which is related to inhibiting the expressions of myostatin and muscle atrophy factors,enhancing the expression of myogenic factors,and improving skeletal muscle microcirculation and insulin resistance.

关 键 词：肌肉萎缩 胰高血糖素样肽-1 胰高血糖素样肽-1类似物 机制 

分 类 号：R587.1[医药卫生—内分泌]