养血透邪法治疗静止期银屑病(血燥证)的临床疗效评价及对血清IL-17的影响  

The clinical effect of nourishing blood and expelling pathogenic factors therapy and its influence to the level of serum IL-17 expressions in the treatment of psoriasis vulgaris of blood-dryness syndrome

作　　者：王英杰[1] 姜珠倩[1] 武宗琴 刘杰[1] 罗瑞静[1] 李淑[1] 柴维汉 彭勇[1] 李斌[2] WANG Yingjie;JIANG Zhuqian;WU Zongqin;LIU Jie;LUO Ruijing;LI Shu;CHAI Weihan;PENG Yong;LI Bin(Department of Dermatology,Jiading Hospital of Traditional Chinese Medicine,Shanghai 201899,China;Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China)

机构地区：[1]上海市嘉定区中医医院,上海201899 [2]上海中医药大学附属岳阳中西医结合医院,上海200437

出　　处：《世界临床药物》2022年第1期56-61,共6页World Clinical Drug

基　　金：上海市卫生和计划生育委员会中医药科研基金课题(2014LP044A);上海市嘉定区卫生和计划生育委员会中医药科研课题(2017-KY-ZYY-11);嘉定区医学重点专科建设项目(JDYXZDZK-7)。

摘　　要：目的探讨养血透邪法治疗静止期银屑病(血燥证)的临床疗效及对血清白介素(interleukin,IL)-17表达水平的影响。方法采用简单排序随机分组法,将符合纳入标准的银屑病患者120例,随机分为养血宣透方治疗组和阿维A胶囊对照组,每组60例,疗程均为8周。观察两组患者治疗后在银屑病临床体征面积和严重程度指数(PASI)、中医证候积分的变化,并采用酶联免疫吸附试验(ELISA)法检测两组患者治疗后血清IL-17表达水平的变化,评价其临床疗效。结果治疗组和对照组总有效率分别为83.33%和86.67%,两组综合疗效相当,差异无统计学意义(P>0.05)。两组治疗8周后,PASI评分、中医证候评分、血清IL-17水平较治疗前均下降,且均具有统计学意义(P<0.05);在改善中医证候评分方面治疗组优于对照组(P<0.01);在降低PASI评分及下调血清IL-17水平方面,两组比较差异无统计学意义(P>0.05)。结论养血透邪法治疗静止期银屑病(血燥证)疗效确切,其作用机制可能与下调血清IL-17的表达水平有关。Objective To evaluate the efficacy of nourishing blood and expelling pathogenic factors therapy for psoriasis vulgaris with blood-dryness syndrome and its influence on the expression of serum interleukin17(IL-17).Methods Simple random grouping method was used,120 cases of psoriasis were randomly divided into the control group(n=60)and the observation group(n=60).The control group was given the Acitretin Capsule and the observation group was treated with Yangxue Xuantou Decoction.The treatment period was 8 weeks.Psoriasis area and severity index(PASI),TCM syndrome integral,and the levels of IL-17 observed after the treatment in the two groups.Results The total effective rate of the observation group and the control group was 83.33%and 86.67%respectively,the total effective rate were comparable in two groups(P>0.05).After the treatment,PASI scores,TCM syndrome integral and the levels of IL-17 were all significantly reduced in the two groups(P<0.05),the score of improving TCM syndrome was superior in treatment group to control group(P<0.01),in terms of reductions PASI scores and the levels of IL-17,the difference between the two groups was no statistically significant(P>0.05).Conclusion Nourishing blood and expelling pathogenic factors therapy is effective for psoriasis with blood-dryness syndrome.The mechanism may be related to the davn-regulation of serum IL-17 expression.

关 键 词：银屑病 血燥证 养血透邪法 汗法 白介素-17 

分 类 号：R969.4[医药卫生—药理学] R275.9[医药卫生—药学]