透明颤菌血红蛋白的结构与功能及其在生物医药生产中的应用  

Structure and Function of Vitreoscilla Hemoglobin and Its Application in the Production of Biomedicines

作　　者：曹艳丽 朱兵峰 时明星 王佩 张贵民 CAO Yanli;ZHU Bingfeng;SHI Mingxing;WANG Pei;ZHANG Guimin(Lunan New Time Bio-Tech Co.,Ltd.,Linyi 273400;National Engineering and Technology Research Center of Chiral Pharmaceutical,Linyi 273400)

机构地区：[1]鲁南新时代生物技术有限公司,山东临沂273400 [2]国家手性制药工程技术研究中心,山东临沂273400

出　　处：《中国医药工业杂志》2022年第1期37-47,共11页Chinese Journal of Pharmaceuticals

摘　　要：透明颤菌血红蛋白(Vitreoscilla hemoglobin,VHb)具有氧结合与传递功能,通过将氧传递到呼吸链,可以改善低氧条件下的细胞呼吸与有氧代谢。VHb在细菌、真菌甚至高等植物中的异源表达在改善细胞生长、促进蛋白质合成以及提高代谢产物产量等方面具有重要作用,特别是在低氧条件下。本综述介绍了VHb的表达调控机制及其结构与功能,重点阐述了VHb的异源表达在天然产物药物、药物前体或医药中间体、保健品功能因子及生物医疗材料等生物医药生产中的应用研究。Vitreoscilla hemoglobin(VHb) holds oxygen binding and transmission functions.By transmitting oxygen to the respiratory chain under hypoxic condition,VHb can improve the respiration and aerobic metabolism of cells.The heterologous expression of VHb in bacteria,fungi,and even higher plants plays an important role in enhancing cell growth,promoting protein synthesis,and increasing the production of metabolites,especially under hypoxic condition.This review introduces the expression regulation mechanism,structure and function of VHb,and it mainly focuses on summarizing the research of VHb heterologous expression in the production of biomedicines,including natural product drugs,prodrugs,pharmaceutical intermediates,functional factors of health products,and biomedical materials.

关 键 词：透明颤菌血红蛋白 异源表达 生物医药 

分 类 号：R915[医药卫生—微生物与生化药学]