从miRNA探索中西药物治疗肾脏病  

Exploring the Treatment of Kidney Disease with Traditional Chinese and Western Medicine from miRNA

作　　者：张永颜 张绍杰 李亚妤[1] ZHANG Yongyan;ZHANG Shaojie;LI Yayu

机构地区：[1]浙江中医药大学附属杭州市中医院,浙江杭州310007 [2]杭州市丁桥医院肾病科,浙江杭州310021

出　　处：《新中医》2022年第3期13-16,共4页New Chinese Medicine

基　　金：浙江省中医药科技计划青年人才基金项目(2021ZQ061)。

摘　　要：近些年肾脏病发病率逐年增加,目前还没有特异性的药物可以逆转肾衰竭进展过程。如何有效地减缓疾病的进展,保护肾功能成为亟待解决的问题。从基因分子水平对肾脏病的中西医药物治疗进行综述。微小RNA (miRNA)一定程度上阐明了药物的作用机制,不仅为降低药物肾脏副作用提供了思路,而且证明了药物的护肾作用,为药物的临床应用提供了理论基础。The incidence rate of kidney disease has increased year by year, and there is no specific drug that can reverse the progression of renal failure. How to effectively slow down the progress of disease and protect renal function has become an urgent problem to be solved. This paper reviews the treatment of kidney disease with traditional Chinese and western medicine at the gene and molecular level. microRNA(miRNA) clarified the action mechanism of drugs to a certain extent,which not only provided ideas for reducing the renal side effects of drugs, but also proved the renal protection effect of drugs, and provided a theoretical basis for the clinical application of drugs.

关 键 词：肾脏病 MIRNA 中西药物 综述 

分 类 号：R692[医药卫生—泌尿科学]