JAK2/STAT3信号通路调节机体免疫功能及针灸干预效应分析  

Analysis of JAK2/STAT3 Signaling Pathway Regulating Immune Function and Acupuncture Intervention Effect

作　　者：毛凯荣 田岳凤 支博远 马晨 MAO Kairong;TIAN Yuefeng;ZHI Boyuan;MA Chen(Shanxi University of Chinese Medicine,Jinzhong 030619,China)

机构地区：[1]山西中医药大学,山西晋中030619

出　　处：《中医药学报》2022年第3期80-85,共6页Acta Chinese Medicine and Pharmacology

基　　金：国家自然科学基金面上项目(81674062,82174504)。

摘　　要：JAK2/STAT3信号转导通路由细胞因子、受体、JAK2、STAT3蛋白和下游基因组成。现代分子免疫学通过对JAK2/STAT3信号转导通路的调节机制进行研究,证明了JAK2/STAT3信号转导通路的免疫调控应用在脂质代谢、血管生成、肿瘤微环境等方面,其机制是在主要通过调控免疫细胞或其他细胞激活相应靶基因、分泌细胞因子来完成的。相关研究表明,针灸能干预JAK2/STAT3信号转导通路的激活,来对脂质代谢异常、脑血管疾病等有治疗作用。但目前研究尚有不足,明确针灸治疗对相关通路调控下游基因的作用机制以及针灸干预效应将有助于更好地认识临床作用。JAK2/STAT3 signal transduction pathway is composed of cytokines,receptors,JAK2,STAT3 proteins and downstream genes.Modern molecular immunology studies the regulatory mechanism of JAK2/STAT3 signaling transduction pathway,and proves that the immune regulation of JAK2/STAT3 signal transduction pathway is applied in lipid metabolism,angiogenesis and tumor microenvironment.Its mechanism is mainly achieved by regulating immune cells or other cells to activate corresponding target genes and secrete cytokines.Studies have shown that acupuncture can interfere with the activation of JAK2/STAT3 signaling transduction pathway to play the role in treating lipid metabolism disorders and cerebrovascular diseases.However,the current research is not perfect.It is helpful for clinical treatment to clarify the mechanism of pathway regulation of downstream genes and the effect of acupuncture intervention.

关 键 词：JAK2/STAT3信号通路 免疫器官 免疫因子 免疫细胞 针灸效应 

分 类 号：R246[医药卫生—针灸推拿学]