血清人附睾蛋白4在多囊卵巢综合征患者妊娠早期的表达及与不良妊娠结局的关系  

The expression of serum human epididymal protein 4 in early pregnancy of patients with polycystic ovary syndrome and its correlation with adverse pregnancy outcome

作　　者：贺春燕 黄伟[1] 周锋[1] 冯光勇[1] 王进 HE Chunyan;HUANG Wei;ZHOU Feng(Department of Endocrinology,Puren Hospital Affiliated to Wuhan University of Science and Technology,Hubei,Wuhan 430081,China)

机构地区：[1]武汉科技大学附属普仁医院内分泌科,武汉市430081

出　　处：《河北医药》2022年第5期733-736,共4页Hebei Medical Journal

基　　金：湖北省卫生健康委员会2019年第一批联合基金立项项目(编号:WJ2019H222)。

摘　　要：目的探讨血清人附睾蛋白4在多囊卵巢综合征患者妊娠早期表达及不良妊娠结局的关系。方法选取2019年4月至2021年4月收治的103例多囊卵巢综合征患者,同期选取健康体检80例健康女性为对照组。采集2组研究对象年龄、体重指数(body mass index,BMI)、收缩压(systolic blood pressure,SBP)、舒张压(diastolic blood pressure,DBP)等一般资料。化学发光微粒子免疫反应法检测血清人附睾蛋白4(humanepididymal protein4,HE4)水平、空腹血糖(fasting blood glucose,FBG)、空腹胰岛素(fasting insulin,FINS),采用稳态模型法计算胰岛素抵抗指数(Insulin resistance index,HOMA-IR)。比较2组临床资料、血清HE4、FBG、FINS、HOMA-IR等指标差异;Logistic回归分析影响多囊卵巢综合征的独立危险因,利用ROC曲线分析血清HE4对多囊卵巢综合征的诊断价值,并分析与不良妊娠结局的关系。结果2组年龄、BMI、SBP、DBP等资料比较差异无统计学意义(P>0.05);Logistic回归分析HE4、FINS、HOMA-IR是影响多囊卵巢综合征的独立危险因素;血清HE4对多囊卵巢综合征和对照组的AUC为0.838,敏感性为61.17%,特异性为93.75%;相关性分析显示,多囊卵巢综合征患者血清HE4表达与FINS、HOMA-IR呈显著正相关关系(P<0.05);多囊卵巢综合征患者血清HE4升高与不良妊娠结局有关。结论多囊卵巢综合征患者血清HE4表达升高,且与不良妊娠结局有关,可作为多囊卵巢综合征诊断的生物标志物。Objective To investigate the expression of serum human epididymal protein 4 in early pregnancy of patients with polycystic ovary syndrome and its correlation with adverse pregnancy outcome.Methods A total of 103 patients with polycystic ovary syndrome who were treated in our hospital from April 2019 to April 2021 were enrolled as observation group,at the same time,the other 80 healthy women who underwent physical examination were enrolled as control group.The general data including age,body mass index(BMI),systolic blood pressure(SBP),and diastolic blood pressure(DBP)were oserved,and the serum levels of human epididymal protein 4(HE4),fasting blood glucose(FBG),and fasting insulin(FINS)were detected by chemiluminescence microparticle immune response method,and insulin resistance index(HOMA-IR)were calculated by using steady-state model method.The clinical data,serum HE4,FBG,FINS,HOMA-IR and related indexes were observed and compared between the two groups.Moreover the independent risk factors affecting polycystic ovary syndrome were analyzed by Logistic regression,and the diagnostic value of serum HE4 for polycystic ovary syndrome was analyzed by ROC curve,and its correlation with adverse pregnancy outcomes was analyzed.Results There were no significant differences in the general information of age,BMI,SBP,and DBP between the two groups(P>0.05).Logistic regression analysis showed that HE4,FINS and HOMA-IR were independent risk factors affecting polycystic ovary syndrome.The AUC of serum HE4 for polycystic ovary syndrome was 0.838,the sensitivity and specificity were 61.17%,93.75%,respectively.Correlation analysis showed that the serum levels of HE4 were positively correlated with FINS and HOMA-IR(P<0.05),and the increased serum levels of HE4 were related with adverse pregnancy outcomes.Conclusion The serum levels of HE4 in patients with polycystic ovary syndrome are increased,which is related to adverse pregnancy outcome and can be regarded as the biomarker for the diagnosis of polycystic ovary syndrome.

关 键 词：多囊卵巢综合征 血清人附睾蛋白4 不良妊娠结局 

分 类 号：R711.75[医药卫生—妇产科学]