全面护理干预对病毒性脑炎患儿神经功能和免疫功能的影响  

Effects of comprehensive nursing intervention on nerve function and immune function of children patients with viral encephalitis

作　　者：薛丽静[1] 姜红[1] XUE Lijing;JIANG Hong(Department of Paediatrics,Central Hospital of Handan City,Hebei,Handan 056001,China)

机构地区：[1]河北省邯郸市中心医院小儿内科,056001

出　　处：《河北医药》2022年第5期791-793,797,共4页Hebei Medical Journal

摘　　要：目的观察全面护理干预对病毒性脑炎患儿神经功能、免疫功能的影响。方法选取2018年10月至2020年3月收治的病毒性脑炎患儿60例,随机分为对照组和试验组,每组30例。对照组采用常规护理模式,试验组采用全面护理模式。观察2组神经损伤因子[神经元特异性烯醇化酶(NSE)、髓磷脂碱性蛋白(MBP)]、炎性因子[白介素6(IL-6)、IL-8、肿瘤坏死因子α(TNF-α)]、氧化应激指标[丙二醛(MDA)、超氧化物歧化酶(SOD)]、T淋巴细胞亚群(CD_(3)^(+)、CD_(4)^(+)、CD_(8)^(+)、CD_(4)^(+)/CD_(8)^(+))、NK细胞、免疫球蛋白(IgG、IgM)变化。结果2组干预前NSE、MBP、IL-6、IL-8、TNF-α、MDA、SOD、CD_(3)^(+)、CD_(4)^(+)、CD_(8)^(+)、CD_(4)^(+)/CD_(8)^(+)、NK、IgG、IgM比较差异无统计学意义(P>0.05);2组干预后NSE、MBP、IL-6、IL-8、TNF-α、MDA、CD_(8)^(+)显著低于干预前,SOD、CD_(3)^(+)、CD_(4)^(+)、CD_(4)^(+)/CD_(8)^(+)、NK、IgG、IgM显著高于干预前(P<0.05),且试验组NSE、MBP、IL-6、IL-8、TNF-α、MDA、CD_(8)^(+)低于对照组(P<0.05),SOD、CD_(3)^(+)、CD_(4)^(+)、CD_(4)^(+)/CD_(8)^(+)、NK、IgG、IgM高于对照组(P<0.05)。结论全面护理干预能够显著降低病毒性脑炎患儿神经损伤因子水平,减轻炎性反应和氧化应激反应,增强细胞免疫和体液免疫功能,从而促进神经功能恢复。Objective To investigate the effects of comprehensive nursing intervention on nerve function and immune function of children patients with viral encephalitis.Methods A total of 60 children patients with viral encephalitis.who were treated from Oct 2018 to Mar 2020 were enrolled in thestudy,who were divided into control group and experimental group,with 30 cases in each group.the patients in control group were treated by routine care interventions,however,thepatients in experimental group were treated by comprehensive nursing intervention.The nerve damage factors(NSE and MBP),inflammatory cytokines(IL-6,IL-8 and TNF-α),oxidative stress indexes(MDA and SOD),T cell subgroups(CD_(3)^(+),CD_(4)^(+),CD_(8)^(+) and CD_(4)^(+)/CD_(8)^(+)),NK cells and immunoglobulin(IgG and IgM)of two groups were observed and compared between the two groups.Results Before nursing,there were no significant differences in levels of NSE,MBP,IL-6,IL-8,TNF-α,MDA,SOD,CD_(3)^(+),CD_(4)^(+),CD_(8)^(+),CD_(4)^(+)/CD_(8)^(+),NK,IgG and IgM between the two groups(P>0.05).After intervention,the levels of NSE,MBP,IL-6,IL-8,TNF-α,MDA and CD_(8)^(+) in both groups were significantly decreased,however,thelevels of SOD,CD_(3)^(+),CD_(4)^(+),CD_(4)^(+)/CD_(8)^(+),NK,IgG and IgM were significantly increased(P<0.05),moreover,the decrease degree and increase degree in experimental group were more significant than those in control group(P<0.05).Conclusion The comprehensive nursing can effectively decrease the levels of nerve damage factors of children patients with viral encephalitis,reduce inflammatory reaction and oxidative stress,enhance the immune function of patients,thereby promoting the recovery of nerve function.

关 键 词：全面护理干预 病毒性脑炎 神经功能 免疫功能 

分 类 号：R725.123[医药卫生—儿科]