血清半乳糖凝集素-3、生长分化因子-15浓度与慢性心力衰竭患者严重程度的相关性分析及其临床诊断价值  

Correlation analysis of serum concentrations of galectin-3,growth differentiation factor-15 with severity of patients with chronic heart failure and their clinical diagnostic value

作　　者：王晶[1] 李培[1] 白玉芝[1] 茹静[1] 汤莉莹[1] 赵霞[1] 田甜[1] 安芸[1] WANG Jing;LI Pei;BAI Yu-zhi;RU Jing;TANG Li-ying;ZHAO Xia;TIAN Tian;AN Yun(Jingxi District,Beijing Chaoyang Hospital,Beijing100043,China)

机构地区：[1]北京朝阳医院京西院区,北京100043

出　　处：《岭南心血管病杂志》2022年第1期59-62,共4页South China Journal of Cardiovascular Diseases

摘　　要：目的探讨血清半乳糖凝集素-3(galectin-3,Gal-3)、生长分化因子-15(growth differentiationfactor-15,GDF-15)浓度与慢性心力衰竭(chronic heartfailure,CHF)患者病情严重程度的相关性,并判断血清Gal-3、GDF-15浓度用于临床诊断的价值。方法选取2018年7月至2019年7月在北京朝阳医院京西院区综合科就诊的CHF患者120例作为研究组,另外选取在本院进行体检的健康者105名作为对照组。分别采用酶联免疫吸附试验(ELISA)法检测血清Gal-3、GDF-15浓度,免疫荧光法检测脑钠肽(brain natriureticpeptide,BNP)、氨基末端脑钠肽前体(N-terminalpro-brainnatriureticpeptide,NT-proBNP)浓度。采用纽约心脏协会(New York Heart Association,NYHA)心功能分级标准将CHF患者心功能进行分级,CHF患者血清Gal-3、GDF-15浓度分别与NYHA分级进行Spearman相关分析。结果与健康体检者相比,CHF患者血清Gal-3、GDF-15浓度显著升高,差异有统计学意义(P<0.05)。与NYHAⅡ级患者相比,NYHAⅢ级、NYHAⅣ级患者血清Gal-3、GDF-15、BNP、NT-proBNP浓度显著升高;与NYHAⅢ级患者相比,NYHAⅣ级患者血清Gal-3、GDF-15、BNP、NTproBNP浓度显著升高,差异有统计学意义(P<0.05)。Spearman分析结果显示,CHF患者血清Gal-3、GDF-15浓度与NYHA分级均呈正相关(r=0.621、0.736,P<0.05)。结论CHF患者血清Gal-3、GDF-15浓度均显著升高,且与NYHA分级均呈正相关。血清Gal-3、GDF-15浓度可以用于CHF的临床诊断或判断心力衰竭的发展进程。Objectives To investigate the correlations between serum concentrations of galectin-3(Gal-3),growth differentiation factor-15(GDF-15)and the severity in patients with chronic heart failure(CHF),and to evaluate the value of serum concentrations of Gal-3 and GDF-15 in clinical diagnosis.Methods Totally 120 patients with CHF from July 2018 to July 2019 in Jingxi District,Beijing Chaoyang Hospital were selected as research group,and 105 healthy people were selected as control group.The serum concentrations of Gal-3 and GDF-15 were detected by enzyme linked immunosorbent assay(ELISA).The concentrations of brain natriuretic peptide(BNP)and N-terminal pro-brain natri⁃uretic peptide(NT-proBNP)were detected by immunofluorescence.The cardiac function of patients with CHF was graded by New York Heart Association(NYHA)classification standard.Correlations between serum concentrations of Gal-3,GDF 15 with NYHA classification in patients with CHF were analyzed by Spearman correlation analysis.Results Compared with healthy people,the serum concentrations of Gal-3 and GDF-15 in patients with CHF were significantly higher(P<0.05).Compared with CHF patients with NYHA gradeⅡ,serum concentrations of Gal-3,GDF-15,BNP and NT-proBNP in CHF patients with NYHA gradeⅢand NYHA gradeⅣwere significantly higher(P<0.05).Compared with CHF patients with NYHA gradeⅢ,the serum concentrations of Gal-3,GDF-15,BNP and NT-proBNP in CHF patients with NYHA gradeⅣwere significantly higher(P<0.05).The results of Spearman analysis showed that the serum concentrations of Gal-3 and GDF-15 positively correlated with NYHA grade(r=0.621,0.736;P<0.05).Conclusions The serum concentrations of Gal-3 and GDF-15 in patients with CHF significantly increase,and they positively correlate with NYHA grading.The serum concentrations of Gal-3 and GDF-15 can be used for clinical diag⁃nosis of CHF or the development process of heart failure.

关 键 词：心力衰竭 半乳糖凝集素-3 生长分化因子-15 临床诊断价值 

分 类 号：R541.6[医药卫生—心血管疾病]