外周血Th1/Th2、COX-2在痛风性关节炎患者中的检测价值分析  

Detection Value of Peripheral Blood Th1/Th2 and COX-2 in Patients with Gouty Arthritis

作　　者：王灿[1] Wang Can(Zhengzhou Orthopaedic Hospital,Zhengzhou 450007)

机构地区：[1]郑州市骨科医院,郑州450007

出　　处：《数理医药学杂志》2022年第3期344-346,共3页Journal of Mathematical Medicine

摘　　要：目的:探析外周血辅助性T细胞(Th1/Th2)、环氧化酶-2(COX-2)在痛风性关节炎(GA)患者中的检测价值。方法:选取2019年3月~2019年12月某院收治的GA患者76例,其中急性期痛风(AG)41例,间歇期痛风(IG)35例,另抽取同期行健康体检者30例作为对照组,分析3组的临床资料以及实验室检查指标,检测3组外周血中Th1/Th2比例以及COX-2水平。结果:IG组与AG组血尿酸、CRP水平高于对照组(P<0.05),AG组的CRP、ESR水平明显高于IG组(P<0.05)。AG组Th1/Th2细胞比例以及COX-2水平较IG组与对照组明显更高(P<0.05)。AG组的Th1细胞比例与ESR正相关,与CRP正相关,与血尿酸负相关(P<0.05);Th2细胞比例与ESR负相关,与CRP正相关(P<0.05)。AG组在治疗第1、3、7、10d的COX-2水平均明显高于对照组与IG组(P<0.05),治疗第14d,3组的COX-2水平比较无统计学差异(P>0.05)。结论:GA患者其外周血中Th1细胞增多伴随着Th2细胞的减少,Th1/Th2失衡在GA的进展中发挥一定的作用,COX-2水平反应镇痛治疗的效果,为临床用药提供依据。Objective:To explore the detection value of peripheral blood helper T cells(Th)1/Th2 and cyclooxygenase-2(COX-2)in patients with gouty arthritis(GA).Methods:A total of 76 patients with GA who were admitted to the hospital from March to December 2019 were enrolled,including 41 cases with acute gout(AG)and 35 cases with intermittent gout(IG).In addition,30 patients who were physically examined in the hospital during the same period were selected as the control group.The clinical data and laboratory examination indexes in the three groups were analyzed.The Th1/Th2 and COX-2 levels in peripheral blood were detected.Results:The levels of blood uric acid and CRP in IG group and AG group were higher than those in control group(P<0.05),levels of CRP and ESR in AG group were significantly higher than those in IG group(P<0.05).Th1/Th2 and COX-2 levels in AG group were significantly higher than those in IG group and control group(P<0.05).In AG group,proportion of Th1 cells was positively correlated with ESR,positively correlated with CRP,and negatively correlated with blood uric acid(P<0.05).The proportion of Th2 cells was negatively correlated with ESR,and positively correlated with CRP(P<0.05).COX-2 level in AG group was significantly higher than that in control group and IG group at 1d,3d,7d and 10d after treatment(P<0.05).At 14d after treatment,there was no significant difference in COX-2 level among the three groups(P>0.05).Conclusion:The Th1 cells increase,while the Th2 cells decrease in peripheral blood of patients with GA.Th1/Th2 imbalance plays certain roles in the progression of GA.COX-2 level can reflect analgesia effect on GA,which provides basis for clinical medication.

关 键 词：关节炎 痛风性 辅助性T细胞1 辅助性T细胞2 环氧化酶-2 

分 类 号：R589[医药卫生—内分泌]