腹膜透析辅助治疗重症肾病综合征合并急性肾损伤临床分析  

Clinical Analysis of Auxiliary Treatment of Peritoneal Dialysis in the Treatment of Severe Nephrotic Syndrome Complicated with Acute Kidney Injury

作　　者：郭嘉鸿[1] 魏华[1] 梁照志 何国斌[1] Guo Jiahong;Wei Hua;Liang Zhaozhi;He Guobin(Xinxiang Central Hospital,Henan Province,Xinxiang 453000)

机构地区：[1]河南省新乡市中心医院,新乡453000

出　　处：《数理医药学杂志》2022年第3期362-365,共4页Journal of Mathematical Medicine

摘　　要：目的:分析腹膜透析在重症肾病综合征(NS)合并急性肾损伤(AKI)患者辅助治疗中的应用效果及安全性。方法:将某院收治的140例重症NS合并AKI患者随机分为F组(腹膜透析组)和X组(血液透析组)各70例,对比两组患者治疗前后的肾功能指标、血蛋白指标、血清炎症反应指标,并统计透析相关并发症的发生率。结果:治疗后,两组患者SCr、BUN、24h尿蛋白量较治疗前均下降(P<0.05),24h尿量均升高(P<0.05),但两组间各指标比较,差异无统计学意义(P>0.05)。治疗后,两组患者白蛋白、总蛋白较治疗前均升高(P<0.05),但两组间白蛋白、血红蛋白、总蛋白比较,差异无统计学意义(P>0.05)。治疗后,两组患者CRP、IL-6、TNF-α较治疗前均下降(P<0.05),F组各指标均低于X组(P<0.05)。F组共10.00%的患者发生并发症,与X组的8.57%比较,差异无统计学意义(P>0.05)。结论:腹膜透析和血液透析对重症NS合并AKI患者肾功能、血蛋白的改善效果及应用安全性效益相当,但腹膜透析对患者微炎症反应的改善效果优于血液透析。Objective:To analyze the efficacy and safety of peritoneal dialysis in the adjunctive treatment of severe nephrotic syndrome(NS)complicated with acute kidney injury(AKI).Methods:A total of 140 patients with severe NS complicated with AKI admitted to a hospital were randomly divided into group F(70 cases,peritoneal dialysis group)and group X(70 cases,hemodialysis group).Renal function indexes,blood protein indexes and serum inflammatory response indexes of the two groups before and after treatment were compared,and the incidence of dialysis-related complications was statistically analyzed.Results:After treatment,SCr,BUN and 24h urine protein in 2 groups were decreased compared with before treatment(P<0.05),24h urine volume was increased(P<0.05),but there was no significant difference between the two groups(P>0.05).After treatment,albumin and total protein in the two groups were increased compared with before treatment(P<0.05),but the comparison of albumin,hemoglobin and total protein between 2 groups showed no significant difference(P>0.05).After treatment,CRP,IL-6 and TNF-α in 2 groups were decreased compared with before treatment(P<0.05),but all indexes in F group were lower than those in X group(P<0.05).Complications occurred in 10%of patients in group F,compared with 8.57%in group X,there was no significant difference(P>0.05).Conclusion:Peritoneal dialysis and hemodialysis have the comparable effect on the improvement of renal function and blood protein,and the safety of application in patients with severe NS complicated with AKI,but peritoneal dialysis has better effect on the improvement of microinflammatory response than hemodialysis.

关 键 词：重症肾病综合征 急性肾损伤 腹膜透析 血液透析 肾功能 炎症反应 

分 类 号：R692.5[医药卫生—泌尿科学]