谷氨酰胺联合法莫替丁在小儿消化道出血预防治疗中的应用及对患儿凝血功能的影响  

Application of Glutamine Combined with Famotidine in the Prevention and Treatment of Gastrointestinal Bleeding in Children and Its Effect on Coagulation Function in Children

作　　者：程林 Cheng Lin(Xuchang Beihai Hospital,Xuchang 461000)

机构地区：[1]许昌北海医院,许昌461000

出　　处：《数理医药学杂志》2022年第3期394-396,共3页Journal of Mathematical Medicine

摘　　要：目的:对谷氨酰胺与法莫替丁在小儿消化道出血预防治疗中的临床应用效果及对患儿凝血功能的影响进行简要的探究和分析。方法:将2020年1月~2020年12月期间在某院诊治的90例小儿消化道出血患儿作为本次研究的观察分析对象,按照数字随机法分为观察组和对照组各45例。对照组实施法莫替丁治疗,观察组在对照组基础上联合谷氨酰胺治疗,对两组患儿的临床总有效率、出血停止时间和隐血转阴时间进行对比,检测两组患儿治疗后的纤维蛋白原、血小板计数、活化部分凝血酶原时间和凝血酶原时间等凝血功能指标。结果:观察组的临床总有效率与对照组存在显著差异,分别为95.56%和80.00%,差异具有统计学意义(P<0.05);治疗后,观察组的出血停止时间和隐血转阴时间均显著短于对照组,差异具有统计学意义(P<0.05);在纤维蛋白原和血小板计数方面,观察组比对照组高;在活化部分凝血酶原时间和凝血酶原时间方面,观察组比对照组低,差异具有统计学意义(P<0.05)。结论:对小儿消化道出血患儿实施谷氨酰胺联合法莫替丁进行治疗,可以加快促进患儿止血和隐血转阴,提高临床治疗总有效率,对改善患儿的凝血功能具有显著的价值和积极意义,值得在临床中进行广泛应用及大力推广。Objective:To briefly explore and analyze the clinical application effect of glutamine and famotidine in the prevention and treatment of gastrointestinal bleeding in children and the effect on the coagulation function of children.Methods:From January 2020 to December 2020,a total of 90 children with gastrointestinal bleeding in a hospital were selected as the object of observation and analysis of this clinical trial study,and divided into the observation group and the control group according to the random number table method,with 45 cases in each group.45 children in the control group were treated with famotidine,and 45 children in the observation group were treated with glutamine on the basis of control group;The total clinical effective rate,stopping time of bleeding,and the time of occult blood becoming negative were compared between the two groups.The blood coagulation function indexes such as fibrinogen,platelet counts,activated partial prothrombin time and prothrombin time of the two groups of children after treatment were detected.Results:The total clinical effective rate of the observation group was significantly different from that of the control group,which were 95.56%and 80%,respectively(P<0.05),and the difference was statistically significant.After treatment,the stopping time of bleeding and the time of occult blood becoming negative in the observation group stopped were significantly shorter than those in the control group(P<0.05),and the difference was statistically significant;In terms of fibrinogen and platelet counts,the observation group was higher than the control group,and in terms of the activated partial prothrombin time and prothrombin time,the observation group was lower than the control group(P<0.05),and the difference was statistically significant.Conclusion:Glutamine combined with famotidine in children with gastrointestinal bleeding can accelerate the promotion of hemostasis and occult blood conversion,and improve the total effective rate of clinical treatment,which has significant valu

关 键 词：小儿消化道出血 谷氨酰胺 法莫替丁 凝血功能 

分 类 号：R725.7[医药卫生—儿科]