全身骨显像与SPECT/CT在马尔尼菲篮状菌感染骨破坏中的诊断价值  

Diagnostic value of whole-body bone imaging and SPECT/CT in bone destruction caused by Talaromyces marneffei

作　　者：孙童 韦智晓[1] 王秀萍[1] 李俊红[1] SUN Tong;WEI Zhixiao;WANG Xiuping;LI Junhong(Department of Nuclear Medicine,The First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China)

机构地区：[1]广西医科大学第一附属医院核医学科,广西南宁530021

出　　处：《分子影像学杂志》2022年第1期44-48,共5页Journal of Molecular Imaging

基　　金：广西卫健委适宜技术项目(S2018077);广西卫健委自筹课题项目(Z2180933)。

摘　　要：目的探讨全身骨显像与SPECT/CT在马尔尼菲篮状菌感染骨破坏中的诊断价值及显像特征分析。方法回顾性分析我院2016年6月~2021年6月于核医学科行全身骨显像及SEPCT/CT断层融合显像的马尔尼菲篮状菌患者47例,其中男25例,女22例,年龄17~72岁,中位年龄51岁。比较全身骨显像、SPECT/CT对马尔尼菲篮状菌骨破坏的诊断效能,并探讨马尔尼菲篮状菌骨破坏的显像特征。结果全身骨显像,SPECT/CT断层融合显像对马尔尼菲篮状菌骨破坏诊断符合率比较,差异有统计学意义(P<0.05)。全身骨平面显像对骨破坏的诊断敏感度为84.4%,特异性为100%,诊断符合率85.1%;SPECT/CT对TM骨破坏的诊断敏感度为97.8%,特异性为100%,诊断符合率98.9%。马尔尼菲篮状菌骨破坏主要侵犯中轴骨,并伴有全身多个位置受累,四肢骨及颅骨为其相对特异性的侵犯位置。结论全身骨显像可以一次性观察全身病灶,在病变的早期即可检出骨质代谢的异常活跃,SPECT/CT诊断符合率较高,二者联合对马尔尼菲篮状菌骨破坏具有很好的应用价值。Objective To explore the diagnostic value and imaging characteristics of whole-body bone imaging and SPECT/CT in bone destruction caused by Talaromyces marneffei.Methods We retrospectively analyzed 47 patients with Talaromyces marneffei who underwent whole-body bone imaging and SPECT/CT tomographic fusion imaging in the Department of Nuclear Medicine in our hospital from June 2016 to June 2021,including 25 males and 22 females,aged from 17 to 72 years old,with a median age of 51 years.We compared the diagnostic efficacy of whole-body bone imaging and SPECT/CT in bone destruction,and discussed the imaging characteristics of bone destruction.Results There was a significant difference in the coincidence rate of whole-body bone imaging and SPECT/CT tomographic fusion imaging in the diagnosis of bone destruction caused by Talaromyces marneffei(P<0.05).The sensitivity of whole-body bone imaging in the diagnosis of bone destruction was 84.4%,the specificity was 100%,and the diagnostic coincidence rate was 85.1%.The diagnostic sensitivity of SPECT/CT for TM bone destruction was 97.8%,the specificity was 100%,and the diagnostic compliance rate was 98.9%.Bone destruction of Talaromyces marneffei mainly affects the axial bones and is associated with the involvement of several locations throughout the body,with the bones of the extremities and the skull being the relatively specific sites of invasion.Conclusion Whole-body bone imaging can observe the whole-body focus at one time,and the abnormal activity of bone metabolism can be detected in the early stage of the lesion.The coincidence rate of SPECT/CT diagnosis is high.The combination of SPECT/CT has a high diagnostic yield and is of good use in the case of bone destruction caused by Talaromyces marneffei.

关 键 词：全身骨显像 SPECT/CT 马尔尼菲篮状菌 骨破坏 

分 类 号：R816.8[医药卫生—放射医学] R68[医药卫生—临床医学]