Prevalence of congenital heart disease among live birth in Hainan,China  

作　　者：ZHANG Du-fei CHEN Ren-wei MO Ze-lai YANG Ling WANG Ya-zhou WANG Hai-fan 张笃飞;陈仁伟;莫泽来;羊玲;王亚洲;王海凡(Cardiovascular Department,Hainan Women and Children's Medical Center,Haikou 570000,China;Cardiac Surgery Department,Hainan Women and Children's Medical Center,Haikou 570000,China;Ultrasound Department,Hainan Women and Children,s Medical Center,Haikou 570000,China;Neonatal Department,Hainan Women and Children's Medical Center,Haikou 570000,China)

机构地区：[1]Cardiovascular Department,Hainan Women and Children's Medical Center,Haikou 570000,China [2]Cardiac Surgery Department,Hainan Women and Children's Medical Center,Haikou 570000,China [3]Ultrasound Department,Hainan Women and Children,s Medical Center,Haikou 570000,China [4]Neonatal Department,Hainan Women and Children's Medical Center,Haikou 570000,China

出　　处：《South China Journal of Cardiology》2021年第4期256-262,278,共8页岭南心血管病杂志（英文版）

基　　金：supported by 2019 Highlevel Talent Project of Hainan Basic and Applied Basic Research Program(Natural Science)(No.2019RC392);Hainan Province Clinical Medical Center Project(No.2021-221)。

摘　　要：Background The prevalence and risk factors of congenital heart disease in Hainan is currently unknown.Methods This study enrolled 117005 consecutive neonates born at delivery institutions of 17 urban and rural regions in Hainan from January 1,2020 to December 31,2020.Cases of CHD were identified by pulse oximetry(POX)combined with auscultation screening,echocardiography,and follow-up.Results A total of 572 newborns(50.7%males)were diagnosed with CHD,providing an overall CHD prevalence of 4.89 per 1000 live births in Hainan,and the prevalence of insignificant,significant,serious and critical CHD was 2.13,2.25,0.28 and 0.23 per 1000 live births,respectively.The most common congenital heart lesion was atrial septal defect(ASD),at a prevalence of 1.889 per 1000.Compared with those without CHD,the proportion of preterm births was obviously higher among the newborns with CHD,especially the newborns with significant and critical CHD.Compared with those without CHD,The proportion of low birthweight infants was obviously higher among the newborns with CHD(serious and critical).In comparison to the Chinese Han population,some other ethnic groups(Miao,Hani and Mi)showed an obviously higher prevalence of CHD.Correlation analysis showed that the prevalence of CHD was positively correlated with altitude(r=0.513,P=0.035).Conclusions Pulse oximetry(POX)combined with auscultation is suitable for CHD screening in remote areas.Premature birth,low birth weight and the rise of altitude were risk factors for CHD.This study obtained accurate data on the prevalence and risk factors of CHD in Hainan,which provided the epidemiological information of CHD in Hainan,China.

关 键 词：congenital heart disease PREVALENCE ethnic group risk factor 

分 类 号：R722.1[医药卫生—儿科]