环状RNA在妊娠期糖尿病病理生理及诊断中的研究进展  

Research progress of circRNAs in pathophysiology and diagnosis of gestational diabetes mellitus

作　　者：张燕萍 陈佳丽 习阳[2] 张宜生[1] ZHANG Yanping;CHEN Jiali;XI Yang;ZHANG Yisheng(The Affiliated Lihuili Hospital,Ningbo University,Ningbo 315048,China;Diabetes Center,Medical School of Ningbo University,Ningbo 315211,China)

机构地区：[1]宁波大学附属李惠利医院,宁波315048 [2]宁波大学医学院糖尿病中心,宁波315211

出　　处：《生命的化学》2021年第12期2606-2613,共8页Chemistry of Life

基　　金：宁波市科技计划性项目(2019C50091);浙江省医药卫生科技计划项目(2022KY297)。

摘　　要：妊娠期糖尿病(gestational diabetes mellitus, GDM)指妊娠期发生或首次发现的不同程度的糖耐量异常,对母体和子代会造成严重影响。GDM的筛查主要依赖孕24~28周口服葡萄糖耐量试验,早期诊断和干预能极大改善不良妊娠结局,但当前缺乏早期预测和诊断GDM的分子标记物。因此,寻找GDM的特异早期诊断标志物,对GDM防治和女性全生命周期管理有重要临床意义。环状RNA(circRNAs)是一种新型的非编码RNA。近年研究发现,circRNAs参与了恶性肿瘤、代谢性疾病、心脑血管疾病等的发生与发展,并有潜力作为早期诊断的分子标记物。CircRNAs与GDM关系密切,在GDM孕妇血清、胎盘组织和脐血中表达差异明显。本文综述了circRNAs在GDM病理生理学中的作用以及作为诊断的分子标志物的研究进展。Gestational diabetes mellitus(GDM) refers to different degrees of glucose tolerance abnormalities that occur during pregnancy, which have serious impact on the mother and the offspring. The screening of GDM mainly relies on the oral glucose tolerance test at 24 to 28 weeks of gestation. The early diagnosis and intervention of GDM can greatly improve pregnancy outcomes. However, molecular markers for early prediction and diagnosis of GDM are currently lacking. Therefore, looking for GDM-specific early diagnosis markers has important clinical significance for the prevention and treatment of GDM and the management of women’s full life cycle. Circular RNA(circRNA) is a new type of non-coding RNA. Recent studies have found that circRNAs are involved in the occurrence and development of malignant tumors, metabolic diseases, cardiovascular and cerebrovascular diseases, etc., and have the potential to be used as a molecular marker for early diagnosis. CircRNAs are differentially expressed in serum, placental tissue, and cord blood of pregnant women with GDM. This review summerized the role of circRNAs in the pathophysiology and research progress as a molecular marker for early diagnosis of GDM.

关 键 词：妊娠期糖尿病 环状RNA 病理生理学 早期诊断 分子标志物 

分 类 号：R714.256[医药卫生—妇产科学]