益生菌对儿童中重度特应性皮炎的辅助治疗  

Probiotics adjuvant treatment in children with moderate to severe atopic dermatitis: a clinical observation

作　　者：杨明[1] 刘晓雁[1] 殷妍[2] 黄小兰[2] YANG Ming;LIU Xiao-yan;YIN Yan;HUANG Xiao-lan(Department of Dermatology,the Affiliated Children′s Hospital of Capital Institute of Pediatrics,Beijing 100020,China;不详)

机构地区：[1]首都儿科研究所附属儿童医院皮肤科,北京100020 [2]首都儿科研究所实验室

出　　处：《中国微生态学杂志》2021年第12期1441-1444,1449,共5页Chinese Journal of Microecology

摘　　要：目的探讨益生菌辅助治疗对儿童中重度特应性皮炎(AD)的临床疗效。方法选择于首都儿科研究所附属儿童医院皮肤科就诊的96例中重度AD患儿为研究对象。入选患儿随机分成两组,其中试验组(50例)患儿给予口服乳杆菌及我院皮肤科AD常规药(口服抗组胺药,外用糠酸莫米松乳膏、我院自制肤乐霜);对照组(46例)患儿仅给予我院皮肤科AD常规药。两组患儿均治疗3个月,治疗前后分别用SCORAD评分、CDLQI评分、DFIQ评分进行病情评估,同时检测两组患儿治疗前后的血清总IgE、IL-2受体、IL-4、嗜酸细胞阳离子蛋白(ECP)水平及Th1/Th2比值。结果治疗后,SCORAD评分显示实验组患儿总有效率为82.0%(41/50),对照组总有效率为52.2%(24/46),两者差异有统计学意义(χ;=6.448,P=0.011)。治疗后,试验组患儿SCORAD评分、CDLQI评分、DFIQ、总IgE水平低于对照组(t=4.656,4.189,3.097、2.278;P<0.001、<0.001、=0.003、=0.025),而IL-2受体、IL-4、ECP、Th1/Th2水平差异无统计学意义(均P>0.05)。结论中重度AD患儿在常规治疗上基础上补充益生菌,可显著降低血清IgE水平,减轻AD患儿的症状,提高疗效。Objective To observe the clinical effect of probiotics adjuvant treatment in children with moderate to severe atopic dermatitis(AD). Methods A total of 96 children with moderate to severe AD treated in our hospital were enrolled and randomly divided into control group(46 cases) or observation group(50 cases). The patients in the observation group were treated with Lactobacillus and conventional medication(Antihistamine, Mometasone furoate cream, hospital-made Fu Le cream), while those in the control group were treated with coventional medication alone. Both groups of patients were treated for 3 months. SCORAD score, CDLQI score and DFIQ score were used to assess the disease condition before and after treatment;the levels of serum total IgE, IL-2 receptor, IL-4, acidocyte cationic protein(ECP) and Thl/Th2 were detected. Results The total efficiency rate in the observation group was much higher than that in the control group(82.0% vs 52.2%, χ;=6.448, P=0.011). After treatment, the SCORAD score, CDLQI score, DFIQ score and level of serum total IgE in the observation group were significantly lower than those in the control group(t=4.656, 4.189, 3.097, 2.278;P<0.001, <0.001, =0.003, =0.025), but there was no significant differences in levels of serum IL-4, IL-2 receptor, ECP and Thl/Th2 between groups. Conclusion Supplement of probiotics based on conventional treatment in children with moderate to severe atopic dermatitis can reduce serum IgE level and the symptoms of AD, and improve the effect of treatment.

关 键 词：益生菌 特应性皮炎 免疫 

分 类 号：R758.23[医药卫生—皮肤病学与性病学]