长链非编码RNA在肝细胞癌中的作用  

Role of Long Noncoding RNA in Hepatocellular Carcinoma

作　　者：张乐佳 庹大云 甘进锋 李金平[1] Zhang Lejia;Tuo Dayun;Gan Jinfeng;Li Jinping(Guilin Medical University, Guilin 541199, China)

机构地区：[1]桂林医学院,广西桂林541199

出　　处：《黑龙江科学》2022年第4期25-27,33,共4页Heilongjiang Science

基　　金：2020年广西学位与研究生教育改革课题(JGY2020160)资助;2021年广西研究生教育创新计划项目(YCSW2021244);广西自然基金面上项目(2017GXNSFAA198134);国家自然基金项目资助(编号81802884)。

摘　　要：原发性肝癌大多是肝细胞癌(Hepatocellular carcinoma,HCC),其发病率和致死率高。为寻找有效的HCC诊疗分子标志物,提高HCC临床疗效,分析了长链非编码RNA(long noncoding RNA,lncRNA)在HCC细胞增殖、凋亡、自噬、侵袭转移中的作用及机制,提出将lncRNA作为新型肿瘤分子诊断标志物进行靶向治疗,以提高HCC诊断水平。Most primary liver cancers are hepatocellular carcinoma(HCC),and the incidence and fatality rate are more.In order to explore effective molecular markers for HCC diagnosis and treatment,and improve the clinical efficacy of HCC,the study analyzes the role and mechanism of long noncoding RNA(lncRNA)in HCC cell proliferation,apoptosis,autophagosome and invasion and metastasis.Targeted treatment can be achieved through lncRNA as new type tumor molecular diagnosis landmark,in order to improve HCC diagnosis level.

关 键 词：长链非编码RNA 肝细胞癌 肿瘤分子标志物 

分 类 号：R735.7[医药卫生—肿瘤]