^(19)F-磁共振造影剂LL02对清醒比格犬心血管及呼吸系统的影响  

Effects of ^(19)F-Magnetic Resonance Imaging Tracer LL02 on the Cardiovascular and Respiratory System in Conscious Beagle Dogs

作　　者：温玉发 丁亚军 王虎斌 乔红群[1] WEN Yufa;DING Yajun;WANG Hubin;QIAO Hongqun(Nanjing Technology University,Nanjing 211816,China;Jiangsu Center for Drug Safety Evaluation,Nanjing 211816,China)

机构地区：[1]南京工业大学,南京211816 [2]江苏省药物安全性评价中心,南京211816

出　　处：《医药导报》2022年第2期186-189,共4页Herald of Medicine

摘　　要：目的探讨^(19)F-磁共振造影剂LL02对清醒状态比格犬心血管和呼吸系统的影响。方法将4只已经成功埋植DSI植入式生理信号遥测采集系统植入子的比格犬随机分成溶媒对照组(0.9%氯化钠注射液)、LL02小剂量组(3μg·kg^(-1))、LL02中剂量组(6μg·kg^(-1))、LL02大剂量组(12μg·kg^(-1)),通过DSI清醒动物生理信号遥测系统连续采集给药前2 h至给药后2 h的数据,并对给药前1 h及给药后(按给药结束时间点计)5,10,15,30,60,90,120 min各个检测点的数据进行分析,检测指标包括心电图(心率、QRS间期、PR间期、QT间期、QTcB),血压(收缩压、舒张压、平均动脉压)、呼吸(潮气量、呼吸频率)。结果与溶媒对照组及本组给药前比较,给药后各时间点,各给药组各项心电指标、血压指标、呼吸指标均差异无统计学意义(P>0.05)。结论静脉注射3,6,12μg·kg^(-1)的LL02对清醒比格犬的心血管和呼吸系统相关指标无明显影响。Objective To evaluate the potential effects of ^(19)F-magnetic resonance imaging tracer LL02 on cardiovascular and respiratory system in conscious Beagle dogs.Methods Four Beagle dogs,which had been successfully implanted DSI telemetry transmitters,were ramdonly designed into four groups,vehicle control group(0.9% sodium chloride injection),low-dose group(3 μg·kg^(-1)),medium-dose group(6 μg·kg^(-1)),and high-dose group(12 μg·kg^(-1)).The ECG(heart rate,QRS interval,PR interval,QT interval,and QTcB),blood pressure(systolic pressure,diastolic pressure,and mean arterial pressure),respiration(tidal volume and respiratory rate),and other indicators were continuously monitored and recorded from 2 h before administration to 2 h after administration,and the data of each detection point at 1 h before administration,5,10,15,30,60,90,and 120 min after administration(according to the end time point of administration)were analyzed.Results Compared with the vehicle control group at the same time point,there was no significant differences in ECG,blood pressure,and respiratory indexes in each treatment group at 2 h after administration(P>0.05).Conclusion No significant changes of cardiovascular and respiratory system in conscious Beagle dogs are observed after intravenous injection of LL02 at the doses of 3,6,and 12 μg·kg^(-1).

关 键 词：^(19)F-磁共振造影剂 LL02 心血管系统 呼吸系统 安全药理学 

分 类 号：R979.6[医药卫生—药品] R965[医药卫生—药学]