急性和缓解期多发性硬化全脑的相干局部一致性研究  

Coherence-based regional homogeneity study of acute and remitting multiple sclerosis

作　　者：朱艳艳 王瑶[1] 何婷 王磊[1] 黄木华 周福庆[1] ZHU Yanyan;WANG Yao;HE Ting;WANG Lei;HUANG Muhua;ZHOU Fuqing(Department of Radiology,the First Affiliated Hospital of Nan Chang University,Nanchang 330006,China)

机构地区：[1]南昌大学第一附属医院放射科,南昌330006

出　　处：《磁共振成像》2022年第3期31-36,共6页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金(编号:81560284)。

摘　　要：目的 探讨急性和缓解期复发-缓解型多发性硬化(relapsing-remitting multiple sclerosis,RRMS)全脑相干局部一致性(coherence-based regional homogeneity,Cohe-ReHo)的变化特点及其临床相关。方法 收集20例急性期RRMS、35例缓解期RRMS以及20例性别、年龄大致匹配的健康对照(healthy control,HC)的静息态功能磁共振成像数据,对所得数据进行Cohe-ReHo计算后,通过方差分析和Post-Hoc检验进行组间比较;随后,将差异有统计学意义脑区的Cohe-ReHo值与患者的扩展残疾状态评分(Expanded Disability Status Scale,EDSS)、进步式听觉累加测试-3s (Paced Auditory Serial Addition Test 3s,PASAT-3s)评分及病程进行偏相关分析。结果 与HC相比,急性和缓解期RRMS的双侧前扣带回和左侧额上回的Cohe-ReHo均显著减低(P<0.001);与HC或缓解期RRMS相比,急性期RRMS右侧楔叶/枕中回Cohe-ReHo升高(P<0.001)。急性期EDSS评分与左侧额上回Cohe-ReHo值呈负相关(r=-0.493,P=0.037),缓解期PASAT-3s评分与左侧额上回Cohe-ReHo值呈负相关(r=-0.382, P=0.028)。结论 急性和缓解期RRMS患者均存在与疾病相关的脑功能活动改变,且缓解期RRMS左侧额上回Cohe-ReHo的异常改变与其认知功能受损有关;相对而言,急性RRMS为尽可能维持功能稳定,调动了更多涉及视觉信息处理的脑区。Objective: To explore the coherence-based regional homogeneity(Cohe-ReHo) alterations of acute and remitting relapsing-remitting multiple sclerosis(RRMS) and it’s clinical relevance. Materials and Methods: Resting-state functional magnetic resonance imaging(rs-fMRI) data were obtained from 20 acute RRMS, 35 remitting RRMS and 20 healthy controls(HC), after the Cohe-ReHo calculation of the rs-fMRI scan, ANOVA and followed Post-hoc analysis was used for comparison between groups;a partial correlation analysis was followed performed on the Cohe-ReHo value in regions with significant differences between groups and the Expanded Disability Status Scale(EDSS), the Paced Auditory Serial Addition Test-3s(PASAT-3s) and the disease duration. Results: Compared with HC, acute and remitting RRMS all showed decreased Cohe-ReHo in the bilateral anterior cingutate and left superior frontal gyrus(P<0.001);compared with HC or remitting RRMS, acute RRMS showed increased Cohe-ReHo in the right cuneus and middle occipital gyrus(P<0.001). EDSS was negatively correlated with the Cohe-ReHo of the left superior frontal gyrus in acute RRMS(r=-0.493, P=0.037) and the PASAT-3 s was negatively correlated with the Cohe-ReHo of the left superior frontal gyrus in remitting RRMS(r=-0.382,P=0.028). Conclusions: Both acute and remitting RRMS patients have disease-related brain dysfunction, while the acute RRMS patients mobilized more brain regions involving visual information processing in an attempt to maintain functional stability.

关 键 词：急性期 缓解期 复发缓解型多发性硬化 相干局部一致性 静息态功能磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R743.1[医药卫生—诊断学]