镍钛合金支架表面修饰进展  

Progress in surface modification of nitinol stent

作　　者：段林 何艳艳[3] 李天晓[3] 陈松 贺迎坤[3] 吴海刚 Duan Lin;He Yanyan;Li Tianxiao;Chen Song;He Yingkun;Wu Haigang(Neurosurgery Department of Stroke Center,Henan University People's Hospital;Henan International Joint Laboratory of Cerebrovascular Disease;Cerebrovascular Department of Interventional Center,Henan Provincial People's Hospital,Henan Zhengzhou 450003;School of Sciences,Henan University,Henan Kaifeng 475004,China)

机构地区：[1]河南大学人民医院卒中中心神经外科,河南郑州450003 [2]河南省脑血管病国际联合实验室 [3]河南省人民医院介入中心脑血管病科 [4]河南大学生命科学院,河南开封475004

出　　处：《中华介入放射学电子杂志》2022年第1期83-87,共5页Chinese Journal of Interventional Radiology：electronic edition

基　　金：河南省高等学校重点科研项目(21A320002);河南省中青年卫生健康科技创新人才培养项目(YXKC2020041);河南省医学科技攻关计划省部共建青年项目(SBGJ202003004)。

摘　　要：近年来生物金属材料已被广泛应用于医疗领域,大多数原材料为钴铬、铁、镁、锌、镍、钛等;其中镍钛合金(NiTi)因具有优异的机械性能和良好的生物相容性,外加微创介入医学的兴起及其在治疗方面对医疗耗材器械精准化的需求,使NiTi在血管介入治疗中被广泛应用。但NiTi支架在生物相容性、耐腐蚀性、术后内皮化延迟及再狭窄等方面的问题仍有待解决。通过对NiTi材料进行精细的设计和适宜的表面涂层修饰,提高医用NiTi的生物相容性和耐腐蚀性,是NiTi未来研究发展的重要方向。文章将从NiTi的生物学特性、表面修饰两个方面,阐述NiTi作为支架材料的研究现状,并系统分析其在血管植入物方面面临的问题。Recently,the biological metal materials have been widely utilized in medicinal implantation,and the main component of these materials are cobalt chromium,iron,magnesium,zinc,nickel and titanium,respectively.Owing to the excellent of mechanical properties and biocompatibility of nitinal,NiTi alloys have been widely applied in vascular interventional treatment.However,the critical unsolved problems of NiTi alloy network contains the immune-response,anti-erosion,delayed endothelialization and restenosis,which have limited the further application in vascular interventional treatments.By precisely regulating the components of coating layers of NiTi alloys,the biocompatibility and anti-erosion can be significantly improved,which is the critical direction for medical alloy surface modification.In this paper,the current research status of NiTi alloys as scaffold material is described from the biological characteristics and surface modification of NiTi alloys,and the problems faced by it in vascular implants are systematically analyzed.

关 键 词：镍钛合金 涂层 生物医用材料 

分 类 号：R318.08[医药卫生—生物医学工程]