Slit-Robo细胞信号转导通路研究进展  

Advances in Slit-Robo Signaling

作　　者：王舒 甘卫冬[3] 金锦祥 施青青 眭承志[3] WANG Shu;GAN Wei-Dong;JIN Jin-Xiang;SHI Qing-Qing;SUI Cheng-Zhi(School of Medicine,Xiamen University,Xiamen 361000,China;The First Affiliated Hospital of Xiamen University,Xiamen 361000,China;School of Rehabilitation Medicine,Nanjing Medical University,Nanjing 210000,China)

机构地区：[1]厦门大学医学院,厦门361000 [2]南京医科大学康复医学院,厦门361000 [3]厦门大学附属第一医院,南京210000

出　　处：《生物化学与生物物理进展》2022年第2期318-327,共10页Progress In Biochemistry and Biophysics

基　　金：福建省自然科学基金(2018J01378)资助项目。

摘　　要：Slit-Robo细胞信号转导通路调控多种多样的生理功能,不同的下游信号转导途径可产生不同的生理功能。其中最广为人知的功能是介导双侧对称生物体胚胎神经系统发育时的轴突排斥现象。近年来,作为一种在生物体内广泛表达的细胞信号转导通路,Slit-Robo的功能库已大大扩展,与神经发育、血管生成、器官及组织发育以及干细胞的增殖调节等均有关。本文就Slit-Robo细胞信号转导通路目前的研究进展做一综述。Slit-Robo regulates many physiologic processes, such as neuronal development, angiogenesis, organ development, cell proliferation, tumor and inflammatory response, and different downstream signal pathways can produce different physiological functions. Moreover, the interaction between Slit and Robo is not one-to-one,many Slit receptors other than Robo have been found, and Robo can also interact with ligands other than Slit.These interactions play a key role in the regulation of cell movement. This article reviews the current research progress of Slit-Robo signal transduction pathways, including the protein structure, proteolytic processing and physiological processes in vivo such as neural development, angiogenesis, organ development, cell proliferation,tumor and inflammatory response. However, the physiological processes of Slit-Robo are highly diverse, and how these differences are regulated remains unknown. We thus expect more basic and translational research.

关 键 词：SLIT ROUNDABOUT Slit-Robo信号转导 

分 类 号：Q28[生物学—细胞生物学] Q291