胞内补体系统的研究进展  

Research progress of intracellular complement system

作　　者：许晅 李璋 马群飞 柳春燕[2] 邵太丽[2] 袁平川 陈靠山(指导)[1] XU Xuan;LI Zhang;MA Qunfei;LIU Chunyan;SHAO Taili;YUAN Pingchuan;CHEN Kaoshan(School of Life Science,Shandong University,Qingdao 266237,China)

机构地区：[1]山东大学生命科学学院,青岛266237 [2]皖南医学院,芜湖241000

出　　处：《中国免疫学杂志》2022年第4期482-487,共6页Chinese Journal of Immunology

基　　金：国家重点研发计划项目(2018YFA0902002);山东省重大专项项目(2015ZDJS04002);安徽省高校自然科学研究重大项目(KJ2021ZD0101)。

摘　　要：胞内补体系统(ICS)是一个相对独立的可调控细胞代谢和功能的胞内生物效应系统。近年研究表明,ICS广泛存在于多种免疫细胞和非免疫细胞,在细胞静息态与激活态维持与转变、基本代谢与增殖分化、凋亡调控等方面具有重要作用。此外,通过对胞内补体的研究也加深了对受补体调节的胞内病原体的认识。更重要的是,胞内补体研究为治疗多种与补体有关的免疫性疾病提供了新的研究思路和方法。Intracellular complement system(ICS)is a relatively independent intracellular biological effector system that can regulate cell metabolism and function. Recent research showed that ICS exists widely in many kinds of cells and plays an indispensable role in maintenance and transformation of resting and active state,basal metabolism,proliferation and differentiation,apoptosis regulation and so on. Research on ICS also makes people have a deeper understanding of complement opsonized intracellular pathogens,which provides new idea and strategies for treatment of many complement related immune diseases more importantly.

关 键 词：胞内补体 免疫细胞 细胞代谢 胞内病原体 

分 类 号：R392[医药卫生—免疫学]