体素内不相干运动扩散加权成像在高级别胶质瘤应用  

APPLICATION OF INTRAVOXEL INCOHERENT MOTION DIFFUSION-WEIGHTED IMAGING IN HIGH-GRADE GLIOMA

作　　者：段崇锋[1] 宋双双 黄凯 牛蕾[1] 刘学军[1] 张丕宁[1] DUAN Chongfeng;SONG Shuangshuang;HUANG Kai;NIU Lei;LIU Xuejun;ZHANG Pining(Department of Radiology,The Affiliated Hospital of Qingdao University,Qingdao 266555,China)

机构地区：[1]青岛大学附属医院放射科,山东青岛266555 [2]首都医科大学宣武医院放射科 [3]昌邑市人民医院普放科

出　　处：《青岛大学学报（医学版）》2022年第1期85-88,共4页Journal of Qingdao University(Medical Sciences)

基　　金：青岛市民生科技计划资助项目(14-2-3-7-nsh)。

摘　　要：目的探讨体素内不相干运动扩散加权成像(IVIM-DWI)在脑高级别胶质瘤瘤体、瘤周水肿区及无病变区域的差异,为三者的鉴别寻求精确的影像技术手段。方法对经病理证实的24例脑高级别胶质瘤病人于术前或放化疗前同时行MR平扫、增强及IVIM-DWI检查,分别测量肿瘤实质、瘤周水肿区(1 cm内)及对侧正常半卵圆中心的灌注系数(D*)、扩散系数(D)、灌注分数(f)值,并进行比较。结果高级别胶质瘤的肿瘤实质、瘤周水肿区(1 cm内)以及对侧正常半卵圆中心的D*、D、f值相比较,差异均有统计学意义(t=-6.636~9.317,P<0.05)。结论IVIM-DWI可区分高级别胶质瘤肿瘤实质和瘤周1 cm水肿区及无病变区域的扩散和灌注差异,为三者的鉴别诊断提供依据。Objective To investigate the difference in intravoxel incoherent motion diffusion-weighted imaging(IVIM-DWI)findings between the parenchyma,peritumoral edema region,and normal region of high-grade glioma,and to determine a precise imaging method for differentiating these regions.Methods MR plain scan,contrast-enhanced MRI,and IVIM-DWI were performed for 24 patients with pathologically confirmed high-grade glioma before surgery or chemoradiotherapy.Pseudodiffusion coefficient of perfusion(D*),diffusion constant(D),and perfusion fraction(f)were measured for and compared between the parenchyma,the peritumoral edema region(within 1 cm),and the contralateral centrum semiovale.Results There were significant differences in D*,D,and f values between the parenchyma,the peritumoral edema region(within 1 cm),and the normal contralateral centrum semiovale of high-grade glioma(t=-6.636-9.317,P<0.05).Conclusion IVIM-DWI can distinguish the differences in diffusion and perfusion between the parenchyma,the peritumoral edema region,and the normal region of high-grade glioma,which provides a basis for the differential diagnosis of the three regions.

关 键 词：神经胶质瘤 脑 弥散磁共振成像 体素内不相干运动 

分 类 号：R445.2[医药卫生—影像医学与核医学] R730.264[医药卫生—诊断学]