子宫内膜异位症不孕患者全胚冷冻和鲜囊胚移植妊娠结局比较  

Comparison of pregnancy outcomes between frozen-all and fresh blastocyst transfer in patients with endometriosis infertility

作　　者：岳彩欣 于倩 张亚男 许鑫鑫 颜磊 Yue Caixin;Yu Qian;Zhang Yanan(Reproductive Hospital Affiliated to Shandong University,Jinan 250012;Shandong Provincial Clinical Research Center for Reproductive Health,Jinan 250012;National Research Center for Assisted Reproductive Technology and Reproductive Genetics,Jinan 250012)

机构地区：[1]山东大学附属生殖医院,济南250012 [2]山东省生殖健康临床医学研究中心,济南250012 [3]国家辅助生殖与优生工程技术研究中心,济南250012

出　　处：《现代妇产科进展》2022年第3期171-175,共5页Progress in Obstetrics and Gynecology

基　　金：国家自然科学基金资助项目(No:82071617)。

摘　　要：目的:比较子宫内膜异位症(EMs)不孕患者行体外受精/卵胞浆内单精子注射(IVF/ICSI)助孕治疗中选择全胚冷冻与鲜囊胚移植的妊娠结局及母婴并发症。方法:选取2014年1月1日至2018年12月31日在山东大学附属生殖医院接受IVF/ICSI治疗的EMs不孕患者,回顾分析活产率、临床妊娠率、累积妊娠率等妊娠结局及母婴并发症。结果:共纳入462例EMs不孕患者,校正混杂因素后,与移植鲜囊胚相比,全胚冷冻可获得较高的累积妊娠率(77.06%vs 61.04%)及较低的生化妊娠流产率(10.20%vs 24.63%)和妊娠期糖尿病(GDM)发生率(1.52%vs 7.20%),两组在其他妊娠结局及母婴并发症方面,差异无统计学意义(P>0.05)。结论:在EMs不孕患者中,全胚冷冻移植可获得较高的累积妊娠率及较低的GDM风险。Objective:To evaluate and compare in vitro fertilization/intracytoplasmic sperm injection(IVF/ICSI)outcomes using frozen-all blastocyst transfer and fresh blastocyst transfer in women with endometriosis infertility.Methods:Select infertility patients with endometriosis received IVF/ICSI treatment in Reproductive Hospital Affiliated to Shandong University from January 1,2014 to December 31,2018.The live birth rate,clinical pregnancy rate,cumulative pregnancy rate and maternal and neonatal complications were retrospectively analyzed.Results:A total of 462 women were included in this study,compared to fresh blastocyst transfer,frozen-all blastocyst transfer resulted in a higher cumulative pregnancy rate(77.06%vs 61.04%),and a lower biochemical pregnancy abortion rate(10.20%vs 24.63%),and gestational diabetes mellitus(GDM)rate(1.52%vs 7.20%).There were no significant differences between groups in other reproductive outcomes and maternal and neonatal complications.Conclusion:Among infertile women with endometriosis,frozen-all blastocyst transfer was associated with a higher cumulative pregnancy rate and a lower risk of GDM than that in fresh blastocyst transfer.

关 键 词：子宫内膜异位症 全胚冷冻 妊娠结局 母婴并发症 累积妊娠率 

分 类 号：R71[医药卫生—妇产科学]