中药雾化联合糠酸莫米松鼻喷雾剂治疗小儿哮喘合并变应性鼻炎的临床疗效  

Clinical efficacy of Chinese medicine atomization combined with Mometasone Furoate Aqueous Nasal Spray in the treatment of children with asthma and allergic rhinitis

作　　者：陈艳春[1] 陈志凌[1] 梅显伟 徐世影[1] 王干[1] 吴佳妮[1] CHEN Yanchun;CHEN Zhiling;MEI Xianwei;XU Shiying;WANG Gan;WU Jiani(Department of Otorhinolaryngology,Hangzhou Hospital of Traditional Chinese Medicine,Hangzhou 310000,China)

机构地区：[1]杭州市中医院耳鼻咽喉科,浙江杭州310000

出　　处：《中国现代医生》2022年第5期94-97,共4页China Modern Doctor

基　　金：浙江省中医药科技计划项目(2021ZA104)。

摘　　要：目的评价中药雾化联合糠酸莫米松鼻喷雾剂治疗小儿哮喘合并变应性鼻炎(AR)的临床疗效。方法选取2018年1月至2019年12月杭州市中医院诊治的58例哮喘伴AR患儿,依治疗差异性分为西医组和联合组,每组各29例,西医组采用糠酸莫米松鼻喷雾剂治疗,联合组采用糠酸莫米松鼻喷雾剂+中药雾化治疗,比较两组的治疗效果。结果用药前比较中医证候积分、炎症因子及通气功能,差异无统计学意义(P>0.05);用药后与西医组比较,联合组中医证候积分:气促胸满(2.01±0.31)分、鼻塞喷嚏(1.51±0.24)分更低(t=7.477、4.374,P<0.05);联合组IL-13(137.24±33.26)ng/L、CRP(13.52±4.17)mg/L指标更低,IFN-γ(45.26±9.43)g/L指标更高(t=2.046、3.076、3.595,P<0.05);联合组FVC(3.89±0.45)L、FEV_(1)(2.69±0.33)L、FEV_(1)/FVC(67.23±14.35)%及PEF(6.72±0.65)L/s指标更高(t=5.278、4.658、2.116、7.025,P<0.05);联合组总有效率(96.55%)高于西医组(79.31%)(χ^(2)=4.062,P=0.044<0.05)。结论中药雾化联合糠酸莫米松鼻喷雾剂治疗小儿哮喘合并AR能提高临床疗效。Objective To evaluate the clinical efficacy of Chinese medicine atomization combined with Mometasone Furoate Aqueous Nasal Spray in treating children with asthma and allergic rhinitis(AR).Methods Data were obtained from 58 children with asthma and AR who were diagnosed and treated in Hangzhou Hospital of Traditional Chinese Medicine from January 2018 to December 2019.The patients were divided into the western medicine group(n=29)treated with Mometasone Furoate Aqueous Nasal Spray and combined group(n=29)treated with Mometasone Furoate Aqueous Nasal Spray+Chinese medicine atomization.The therapeutic effects were compared between the two groups.Results There was no significant difference in TCM syndrome score,inflammatory factors,and ventilation function before treatment(P>0.05).Compared with the western medicine group,TCM syndrome score in the combined group:shortness of breath,chest fullness(2.01±0.31)points,nasal congestion and sneezing(1.51±0.24)points were lower after medication(t=7.477,4.374,P<0.05).The IL-13(137.24±33.26)ng/L and CRP(13.52±4.17)mg/L in the combined group were lower,IFN-γ(45.26±9.43)g/L in the combined group was higher(t=2.046,3.076,3.595,P<0.05).The FVC(3.89±0.45)L,FEV_(1)(2.69±0.33)L,FEV_(1)/FVC(67.23±14.35)%and PEF(6.72±0.65)L/s indicators in the combined group was higher(t=5.278,4.658,2.116,7.025,P<0.05).The total effective rate of the combined group(96.55%)was higher than that of the western medicine group(79.31%)(χ^(2)=4.062,P=0.044<0.05).Conclusion Chinese medicine atomization combined with Mometasone Furoate Aqueous Nasal Spray in treating children with asthma and AR can improve the clinical efficacy.

关 键 词：中药雾化 糠酸莫米松鼻喷雾剂 小儿哮喘 变应性鼻炎 

分 类 号：R725.6[医药卫生—儿科]