曲美他嗪治疗急性病毒性心肌炎的价值分析  

Value analysis of trimetazidine in the treatment of acute viral myocarditis

作　　者：段丽钦 DUAN Li-qin(Department of Cardiovascular Medicine,Dalian Central Hospital,Dalian 116003,China)

机构地区：[1]大连市中心医院心血管内科,116003

出　　处：《中国实用医药》2022年第5期9-11,共3页China Practical Medicine

摘　　要：目的 分析曲美他嗪治疗急性病毒性心肌炎的价值。方法 100例急性病毒性心肌炎患者,遵从“乱数表法”分配原则分为参照组和研究组,每组50例。参照组行常规治疗,研究组在参照组基础上行曲美他嗪治疗。比较两组患者的不良反应发生情况、生活质量评分、血清炎症指标[超敏C反应蛋白(hs-CRP)、白细胞介素6(IL-6)、肿瘤坏死因子-α(TNF-α)]。结果 研究组患者不良反应发生率40.00%低于参照组的72.00%,差异具有统计学意义(P<0.05)。研究组患者的社会功能、躯体功能、情感健康、心理健康评分分别为(77.32±14.85)、(73.65±13.20)、(75.36±15.28)、(78.26±17.95)分,均高于参照组的(64.21±11.40)、(64.25±11.05)、(60.32±10.03)、(65.27±11.95)分,差异有统计学意义(P<0.05)。研究组患者的血清hs-CRP(5.39±1.56)mg/L、IL-6(11.89±1.69)pg/ml、TNF-α(18.69±2.32)pg/ml均低于参照组的(6.55±1.63)mg/L、(14.69±2.86)pg/ml、(22.56±3.69)pg/ml,差异有统计学意义(P<0.05)。结论 急性病毒性心肌炎患者行曲美他嗪治疗可明显减少不良反应发生情况,进一步提高患者的生活质量,同时可改善患者的血清炎症指标,改善患者的心肌炎症,值得临床推广。Objective To analyze the value of trimetazidine in the treatment of acute viral myocarditis.Methods A total of 100 patients with acute viral myocarditis were divided into the reference group and the research group according to the"random number table method"allocation principle,with 50 cases in each group.The reference group received conventional treatment,and the research group received trimetazidine treatment on the basis of the reference group.Both groups were compared in terms of occurrence of adverse reactions,quality of life scores,serum inflammatory indicators[high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)].Results The incidence of adverse reactions 40.00%in the research group was lower than 72.00%in the reference group,and the difference was statistically significant(P<0.05).The scores of social function,physical function,emotional health,and mental health of the research group were(77.32±14.85),(73.65±13.20),(75.36±15.28),and(78.26±17.95)points,which were all higher than(64.21±11.40),(64.25±11.05),(60.32±10.03),and(65.27±11.95)points of the reference group,and the difference was statistically significant(P<0.05).The serum hs-CRP(5.39±1.56)mg/L,IL-6(11.89±1.69)pg/ml,and TNF-α(18.69±2.32)pg/ml of the research group were lower than(6.55±1.63)mg/L,(14.69±2.86)pg/ml,and(22.56±3.69)pg/ml of the reference group,and the difference was statistically significant(P<0.05).Conclusion Trimetazidine treatment in patients with acute viral myocarditis can significantly reduce the occurrence of adverse reactions and further improve the quality of life of patients,while improving the serum inflammation index and myocardial inflammation of patients,which is worthy of clinical promotion.

关 键 词：曲美他嗪 急性病毒性心肌炎 血清炎症指标 不良反应 生活质量 

分 类 号：R542.21[医药卫生—心血管疾病]