胺碘酮治疗急性心肌梗死伴心房颤动对患者心率及P-R间期的影响  

Effect of amiodarone on heart rate and P-R interval in patients with acute myocardial infarction and atrial fibrillation

作　　者：王振坤 叶志松 WANG Zhenkun;YE Zhisong(Department of Cardiovascular Medicine,Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine(Zhuhai Second People's Hospital),Zhuhai519000,China)

机构地区：[1]珠海市中西医结合医院(珠海市第二人民医院)心血管内科,广东珠海519000

出　　处：《中国现代医生》2022年第4期56-59,共4页China Modern Doctor

摘　　要：目的探究胺碘酮治疗急性心肌梗死伴心房颤动对患者心率及P-R间期的影响。方法选择2018年1月至2021年1月在珠海市中西医结合医院(珠海市第二人民医院)接受治疗的急性心肌梗死伴心房颤动患者126例,随机分为研究组、对照组,对照组进行常规治疗,研究组进行胺碘酮治疗。比较两组的血压、心率、P-R间期、治疗效果、不良反应、心功能。结果治疗后,两组的收缩压、心率均明显降低,P-R间期均明显延长,但较对照组,研究组变化更明显,差异有统计学意义(P<0.05);与对照组比较,研究组治疗总有效率更高,不良反应总发生率更低,差异有统计学意义(P<0.05);对照组较研究组,左心室收缩末期内径(LVESD)、心室舒张末期内径(LVEDD)水平更低,每分心排量(CO)、左心室射血分数(LVEF)水平更高,差异有统计学意义(P<0.05)。结论在急性心肌梗死伴心房颤动患者临床治疗中,胺碘酮治疗发挥重要作用,可改善患者血压、心率及心功能,且预后效果理想,治疗有效率高。因此,胺碘酮治疗值得广泛应用。Objective To investigate the effect of amiodarone on heart rate and P-R interval in patients with acute myocardial infarction and atrial fibrillation.Methods A total of 126 patients with acute myocardial infarction complicated with atrial fibrillation who received treatment in Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine(Zhuhai Second People's Hospital)from January 2018 to January 2021 were selected and randomly divided into the study group and the control group.The control group received routine treatment.The study group received amiodarone treatment.Blood pressure,heart rate,P-R interval,therapeutic effect,adverse reactions,and cardiac function were compared between the two groups.Results After treatment,systolic blood pressure and heart rate were significantly reduced,and the P-R interval was significantly prolonged in both groups.Compared with the control group,the change was more significant in the study group,and the difference had statistical significance(P<0.05).Compared with the control group,the observation group's total treatment efficiency was higher,the total incidence rate of adverse reactions was lower,and the difference had statistical significance(P<0.05).Compared with the study group,the end-systolic diameter of the left ventricle(LVESD)and end-diastolic diameter of the ventricle(LVEDD)levels were lower,and the minute cardiac output(CO)and left ventricular ejection fraction(LVEF)levels were significantly higher,and the difference was statistically significant(P<0.05).Conclusion Amiodarone plays an important role in treating patients with acute myocardial infarction and atrial fibrillation.It can improve blood pressure,heart rate,and cardiac function,and has an ideal prognosis and high treatment efficiency.Therefore,amiodarone therapy is worthy of extensive application.

关 键 词：胺碘酮 急性心肌梗死 心房颤动 心率 P-R间期 心功能 

分 类 号：R542.2[医药卫生—心血管疾病]