病理性黄疸患儿治疗前血清转铁蛋白、α-谷胱甘肽-s-转移酶表达与蓝光间歇治疗效果的相关性  

Correlation between the expression of serum transferrin andα-glutathione-s-transferase before treatment and the effect of blue light intermittent therapy in children with pathological jaundice

作　　者：郑静 郑盛华 应雪娜 ZHENG Jing;ZHENG Sheng-hua;YING Xue-na(First People's Hospital of Daishan County,Daishan,Zhejiang 316200,China)

机构地区：[1]岱山县第一人民医院,浙江岱山316200

出　　处：《中国卫生检验杂志》2022年第3期345-349,共5页Chinese Journal of Health Laboratory Technology

摘　　要：目的分析病理性黄疸患儿经蓝光间歇治疗的效果与血清转铁蛋白(TRF)、α-谷胱甘肽-s-转移酶(α-GST)表达的关系,指导未来病理性黄疸患儿蓝光间歇治疗方案的优化。方法选取2018年1月—2019年12月在医院拟接受蓝光间歇治疗的98例病理性黄疸患儿,治疗实施前为患儿检测血清TRF、α-GST水平,持续治疗7 d,评估治疗效果,并根据治疗效果分为无效组与有效组,调查2组患儿基线资料,观察TRF、α-GST水平与病理性黄疸患儿经蓝光间歇治疗无效的关系及其对治疗无效风险的预测价值。结果98例病理性黄疸患儿经蓝光间歇治疗7 d,治疗总有效率为85.71%(84/98);无效组血清TRF水平低于有效组,α-GST水平高于有效组,差异均有统计学意义(P<0.05);病理性黄疸患儿的血清TRF水平与α-GST水平之间呈负相关(r=-0.592,P<0.001)。二元Logistic回归分析显示血清TRF过表达、α-GST低表达均是病理性黄疸患儿经蓝光间歇治疗无效的影响因素(P<0.05)。绘制ROC曲线结果显示,血清TRF、α-GST水平预测病理性黄疸患儿经蓝光间歇治疗无效风险的AUC均>0.80,预测价值理想。结论病理性黄疸患儿经蓝光间歇治疗无效可能与治疗前血清TRF、α-GST表达有关,临床可考虑治疗前测定患儿血清TRF、α-GST水平,预测治疗无效风险,指导早期治疗方案调整。Objective To analyze the relationship between the effect of intermittent blue light therapy and the expression of serum transferrin(TRF)andα-glutathione-s-transferase(α-GST)in children with pathological jaundice,so as to guide the optimization of blue light intermittent treatment in children with pathological jaundice in the future.Methods From January 2018 to December 2019,98 children with pathological jaundice who prepared to receive blue light intermittent therapy in the hospital were selected.Before treatment,serum TRF andα-GST levels of children were detected.After 7 days of treatment,the therapeutic effect was evaluated.According to the therapeutic effect,the patients were divided into an ineffective group and an effective group,the baseline data of the two groups were investigated to observe the relationship between the levels of TRF andα-GST in children with pathological jaundice after intermittent blue light therapy and their predictive value for the risk of ineffective treatment.Results Of 98 children with pathological jaundice after 7 d of blue light intermittent therapy,the total effective rate was 85.71%(84/98);the serum TRF level in the ineffective group was lower than that in the effective group,and theα-GST level was higher than that in the effective group,with the difference statistically significant(P<0.05).Correlation analysis showed that there was a negative correlation between serum TRF level andα-GST level in children with pathological jaundice(r=-0.592,P<0.001).After binary Logistic regression analysis showed that the over expression of serum TRF and the low expression ofα-GST were the influencing factors of blue light intermittent therapy in children with pathological jaundice(P<0.05).The ROC curve showed that the AUC of serum TRF andα-GST levels in predicting the risk of failure after intermittent blue light therapy in children with pathological jaundice was higher than 0.80,showing ideal predictive value.Conclusion The failure of intermittent blue light therapy in children with p

关 键 词：病理性黄疸 蓝光间歇治疗 转铁蛋白 α-谷胱甘肽-s-转移酶 疗效 相关性 

分 类 号：R722.17[医药卫生—儿科]