诱发支气管哮喘动物模型气道重塑特征的方法和评价  

Methods and evaluation of airway remodeling characteristics in animal models of bronchial asthma

作　　者：何婷 钱佩瑶 洪敏[1] 刘成勇[2] 郑劼 HE Ting;QIAN Peiyao;HONG Min;LIU Chengyong;ZHENG Jie(School of Pharmacy,Nanjing University of Chinese Medicine,Jiangsu Province Key Laboratory of Pharmacology and Safety Evaluation of Chinese Materia Medicine,Nanjing 210023;China.2.Hospital of Nanjing University of Chinese Medicine,Nanjing 210029;.3.Nanjing University of Chinese Medicine School of Medicine and Holistic Integrateive Medicine,Nanjing 210023)

机构地区：[1]南京中医药大学药学院江苏省中药药效与安全性评价重点实验室,南京210023 [2]南京中医药大学附属医院,南京210029 [3]南京中医药大学医学院·整合医学学院,南京210023

出　　处：《中国实验动物学报》2022年第1期117-123,共7页Acta Laboratorium Animalis Scientia Sinica

基　　金：国家自然科学青年科学基金项目(81904282)。

摘　　要：气道重塑是慢性哮喘最复杂的病理基础之一,建立具有气道重塑特征的支气管哮喘动物模型对评价药效及阐明病理机制的研究具有重要的意义。通过对相关动物模型进行分析比较,总结可行的支气管哮喘气道重塑动物模型构建方法。Airway remodeling is one of the most complicated pathological characteristics of chronic asthma.The establishment of an animal model of bronchial asthma with airway remodeling characteristics has great significance to evaluate treatment efficacy and to elucidate the pathological mechanisms of chronic asthma.Based on the analysis and comparison of published asthma animal models,the method ology of feasible animal models of airway remodeling for bronchial asthma was summarized in the current review.

关 键 词：支气管哮喘 气道重塑 动物模型 TH2型细胞因子 

分 类 号：Q95-33[生物学—动物学]